Registration Dossier
Registration Dossier
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EC number: 601-489-9 | CAS number: 1176-81-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Study period:
- 18 Nov 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.84
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: 95 % confidence limits 2.64-3.03
- Conclusions:
- For Fluocortolon-A-Acetat the n-octanol/water partition coefficient (logPow) is 2.84 (95 % confidence limits 2.64-3.03) measured at 25 °C and pH 7.
- Executive summary:
For Fluocortolon-A-Acetat the n-octanol/water partition coefficient (logPow) was determined with the HPLC-method according to OECD guideline 117 to be 2.84 (95 % confidence limits 2.64 -3.03) measured at 25 °C and pH 7. This method is based on the correlation of the reversed phase retention data of the test compound with those of the reference compounds with known log Pow values. Fluocortolon-A-Acetat can be considered as a neutral molecule in the pH range of physiological interest. Therefore, no pH dependence of log Pow has to be taken into account.
Reference
No validity criteria were applied as this evaluation is based on an expert statement.
Description of key information
For Fluocortolon-A-Acetat the n-octanol/water partition coefficient (logPow) is 2.84 (95 % confidence limits 2.64 -3.03) measured at 25 °C and pH 7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.84
- at the temperature of:
- 25 °C
Additional information
Fluocortolon-A-Acetat can be considered as a substance with low lipophilicity.
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