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Diss Factsheets
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EC number: 204-427-5 | CAS number: 120-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- The purity of the test substance and the strain of rat used are not known. The administration volume and the use of vehicle are not specified.
Data source
Reference
- Reference Type:
- publication
- Title:
- The benzenediols: catechol, resorcinol and hydroquinone: a review of the industrial toxicology and current industrial exposure limits.
- Author:
- Flickinger C.W.
- Year:
- 1 976
- Bibliographic source:
- American Industrial Hygiene Association Journal, 37(10), 596-606.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Federal register (see below)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Federal Register (1961) pp. 7333-7341, Part 191- Hazardous Substances: Definitions and Procedural and Interpretative Regulations, Final Order
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Pyrocatechol
- EC Number:
- 204-427-5
- EC Name:
- Pyrocatechol
- Cas Number:
- 120-80-9
- Molecular formula:
- C6H6O2
- IUPAC Name:
- pyrocatechol
- Details on test material:
- Koppers Company, Inc, Catechol C.P. Crystal Lot 68-1.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 158, 316, 630 and 1260 mg/kg bw
- No. of animals per sex per dose:
- 5 males per dose
- Control animals:
- yes
- Details on study design:
- - Rats were observed during a 14-day post-exposure period.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 300 mg/kg bw
- 95% CL:
- 200 - 500
- Mortality:
- 0/5 rat died at the dose of 158 mg/kg bw.
2/5 rats died at the dose of 316 mg/kg bw on day 1 and 2.
5/5 rats died at the dose of 630 mg/kg bw by day 1.
5/5 rats died at the dose of 1260 mg/kg bw within 1 hour. - Clinical signs:
- other: other: no data
- Gross pathology:
- None of the rats sacrificed following the holding period exhibited any gross lesions upon pathological examination.
- Other findings:
- The rats that died during the observation period revealed hyperaemia of the stomach and intestine.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Based on this study, Catechol is classified as Acute. Tox. Category 3, H301 according to EU GHS Regulation.
- Executive summary:
In an acute oral toxicity study (Flickinger, 1967), groups of 5 albino male rats were given a single oral dose of catechol at doses of 0, 158, 316, 630 and 1260 mg/kg bw and observed for 14 days.
No death occured at 158 mg/kg bw, 2/5 died at 316 mg/kg bw and 5/5 at 630 mg/kg bw.
No clinical signs were reported and the autopsy revealed for rats died during the study: hyperemia of the stomach and intestines. None of the rats sacrifed at the end of the experiment revealed gross pathology during pathological examination.
Oral LD50Males = 300 mg/kg bw (95% C.L. 200-500 mg/kg)
Catechol is considered to be toxic if swallowed based on the LD50 obtained.
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