Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-404-7 | CAS number: 106-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48-h EC50 value in Daphnia magna is 0.280 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 0.28 mg/L
Additional information
A total of six studies with aquatic invertebrates are available for evaluation, a flow-through study with the amphipod Gammarus fasciatus and an additional five studies with Dapnia magna.
In the first study, Gammarus fasciatus (non-standard species) was exposed to the test substance under flow-through conditions which is the preferred approach given the substances degradation behavior in water (Resource Analysts, Inc., 1990). The study was not conducted in accordance with generally accepted test guidelines but reporting is detailed and the study design shows no restrictions. Mean measured recoveries were ≥79%.
All Daphnia studies were conducted in accordance with GLP and OECD TG 202 or similar test guidelines. Two of the studies were conducted using a static test design (Haskell Laboratory, 1985c/d). In both these studies test substance analysis revealed that at the start of the test (t=0) recoveries decreased from 50-60% to 11-19%. Therefore, it was decided that no analysis was performed at the end of the 48-hour exposure period. In addition, two of the Daphnia studies were performed under semi-static conditions with renewal of test solution every 24 hours (Haskell Laboratory, 1990; Japan Food Research Laboratories, 2002). In these studies, test concentrations were not reported. The final Daphnia study was performed to get a better understanding of the behavior of the substance in the test medium and thereby improve the data in the REACH dossier submitted in 2010. In this new semi-static study additional emphasis was put on test substance analysis (a semi-static design was preferred over flow-through as the latter gave methodological difficulties). Recovery rates of test item in the fresh media (0 and 24 hours) were in the range of 96 to 105 % of the nominal values at all tested concentration levels. The recovery rates in the old media (24 and 48 hours) were in the range of 26 to 73 % of the nominal values. The geometric mean recovery rates were in the range of 50 to 82 %.
Although in the older Daphnia studies test substance recoveries at the end of the test were not determined, in most of these studies a (nominal) concentration-dependent increase in toxicity is reported. Overall, the effect concentrations obtained from the Daphnia studies are significantly lower than that observed in in Gammarus fasciatus. Therefore, despite the limitations in design and reporting, daphnids are considered to be the most sensitive species. As five studies are available with the same species and test design, a geomean effect concentration was calculated based on all reported effect concentrations. Considering that especially in the older studies test concentrations were not well-maintained and the results obtained may thus over-estimate the toxicity of the substance, this approach may be considered conservative. A calculated geometric mean 48-h EC50 value of 0.280 mg/L is considered for assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.