Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-759-1 | CAS number: 13476-99-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- no details given
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250g and 290g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
- Type of coverage:
- occlusive
- Vehicle:
- other: 0.8% aqueous hydroxypropyl-methyl-cellulose gel
- Details on dermal exposure:
- The hair on the site of application was clipped with hair-clippers, without causing injury, approximately 24 hours before application.
The site was situated on the animal's back between the fore and hind extremitites and had an area of approx. 5 x 6 cm (=1/10 body surface).
The test substance was applied to 8 layers of gauze and then to the application site. The patch was covered with a plastic sheet and secured with adhesive plaster. - Duration of exposure:
- 24 hours
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration; then twice daily for a period of 14 days
- Frequency of body weights: before administration, then weekly for a period of 14 days
- Necropsy of survivors performed: yes - Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- other: no-effect level
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no signs of toxicity were observed
- Mortality:
- Mortality did not occur in treated animals.
- Clinical signs:
- other: No signs of toxicity were observed following dermal application.
- Other findings:
- No signs of toxicity were observed following dermal application.
- Conclusions:
- No mortality occurred at a tested level of 2500 mg/kg bw. The LD50 is considered to be more than 2500 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study (limit test similar to OECD Guideline 402), groups of Sprague-Dawley rats (5/group) were given a single dermal dose of vanadium pentoxide, at 2500 mg/kg bw and observed for 14 days. No mortality occurred in this test; therefore an exact LD50 has not been determined. The test article vanadium pentoxide, when administered dermally as received to 5 Sprague Dawley rats had an acute dermal LD50 of greater than 2.5 g/kg bw. No evidence of systemic toxicity was observed.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250g and 290g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- > 7.22 - < 13.26 µm
- Remark on MMAD/GSD:
- An analysis of the particle size distribution was carried out twice during the exposure period using a cascade impactor according to May (May K. R. (1975) J. Aerosol. Sei. 6: 413).
The dust from the exposure chamber was sucked through the cascade impactor for 1.5 to 5 min at a constant flow rate of 5 l/min. The slides covered with adhesive tape were removed from the impactor and were weighted on an analytical balance (precision 10 µg). The mass median aerodynamic diameter (MMAD) was estimated by means of nonlinear regression analysis (Litchfield and Wilcoxon, (1949) J. Pharmacol. 95: 99). - Details on inhalation exposure:
- Analysis of the Dust Concentration:
The dust concentration in the inhalation chamber was measured with an air sample filter (Sartorius Minisart SM 17598). Dust samples were taken during the first half and during the second half of the exposure. For that purpose, Minisart SM 17598 filters were placed close to the animals' nose and sucked through with a constant flow of air of 300 l/h for 1 to 3 min. The filters were weighed before and after sampling. Concentration of the test substance in the air was calculated as mg/l. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
- Details on study design:
- The study was carried out using a dynamic inhalation apparatus with a nose only exposure of the animals. The apparatus consists of a cylindrical exposure chamber (volume 40 l) which holds a maximum of 20 animals in pyrex tubes at the edge of the chamber in a radial position.
The dust was generated with a dust generator and dosing apparatus. The generator was fed with compressed air from a compressor. At the bottom of the exposure chamber the air was sucked off at a similar rate as created by the dust generator, in order to produce a homogeneous distribution in the exposure chamber. At least 12 air changes per hour were carried out. Air-flow meters were used to control the constant supply of compressed air and vacuum. Flow rates were checked at least once hour and corrected if necessary. Exposure time was 4 hours. - Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 2.61 mg/L air
- Based on:
- not specified
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 2.43 mg/L air
- Based on:
- not specified
- Sex:
- male
- Dose descriptor:
- other: No-effect level
- Effect level:
- 0.72 mg/L air
- Based on:
- not specified
- Sex:
- female
- Dose descriptor:
- other: No-effect level
- Effect level:
- 1.21 mg/L air
- Based on:
- not specified
- Mortality:
- Animals died up to 8 days after the inhalative exposure.
- Other findings:
- Histopathological examination of the lungs of the animals that received inhalative exposure revealed haemorrhage, vascular congestion and oedema in the lungs and bronchopneumonia.
- Conclusions:
- LC50 = 2.61 mg/L (male rats), 2.43 mg/L (female rats)
- Executive summary:
Rats were exposed to dust of ammonium vanadate (NH4VO3, CAS 7803 -55 -6) for 4 hours (nose only). Animals died up to 8 days after the inhalative exposure. Histopathological examination of the lungs of the animals that received inhalative exposure revealed haemorrhage, vascular congestion and oedema in the lungs and bronchopneumonia. The LC50-values for V2O3(analytical grade, powder) is 6.65 mg/L in female rats. The LC50-values for the NH4VO3 test-substance following inhalative exposure were 2.61 mg/L for male and 2.43 mg/L for female rats.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250g and 290g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- > 15.14 - < 19.48 µm
- Remark on MMAD/GSD:
- An analysis of the particle size distribution was carried out twice during the exposure period using a cascade impactor according to May (May K. R. (1975) J. Aerosol. Sei. 6: 413).
The dust from the exposure chamber was sucked through the cascade impactor for 1.5 to 5 min at a constant flow rate of 5 l/min. The slides covered with adhesive tape were removed from the impactor and were weighted on an analytical balance (precision 10 µg). The mass median aerodynamic diameter (MMAD) was estimated by means of nonlinear regression analysis (Litchfield and Wilcoxon, (1949) J. Pharmacol. 95: 99). - Details on inhalation exposure:
- Analysis of the Dust Concentration:
The dust concentration in the inhalation chamber was measured with an air sample filter (Sartorius Minisart SM 17598). Dust samples were taken during the first half and during the second half of the exposure. For that purpose, Minisart SM 17598 filters were placed close to the animals' nose and sucked through with a constant flow of air of 300 l/h for 1 to 3 min. The filters were weighed before and after sampling. Concentration of the test substance in the air was calculated as mg/l. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
- Details on study design:
- The study was carried out using a dynamic inhalation apparatus with a nose only exposure of the animals. The apparatus consists of a cylindrical exposure chamber (volume 40 l) which holds a maximum of 20 animals in pyrex tubes at the edge of the chamber in a radial position.
The dust was generated with a dust generator and dosing apparatus. The generator was fed with compressed air from a compressor. At the bottom of the exposure chamber the air was sucked off at a similar rate as created by the dust generator, in order to produce a homogeneous distribution in the exposure chamber. At least 12 air changes per hour were carried out. Air-flow meters were used to control the constant supply of compressed air and vacuum. Flow rates were checked at least once hour and corrected if necessary. Exposure time was 4 hours. - Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
- Sex:
- male
- Dose descriptor:
- LC50
- Remarks on result:
- not determinable
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 6.65 mg/L air
- Based on:
- not specified
- Sex:
- male
- Dose descriptor:
- other: No-effect level
- Remarks on result:
- not determinable
- Sex:
- female
- Dose descriptor:
- other: No-effect level
- Effect level:
- > 6.65 mg/L air
- Based on:
- not specified
- Mortality:
- Animals died up to 8 days after the inhalative exposure.
- Other findings:
- Histopathological examination of the lungs of the animals that received inhalative exposure revealed haemorrhage, vascular congestion and oedema in the lungs and bronchopneumonia.
- Conclusions:
- LC50 > 6.65 mg/l (female rats)
- Executive summary:
Rats were exposed to dust of vanadium (III) oxide (V2O3,CAS 1314 -34 -7) for 4 hours (nose only). Animals died up to 8 days after the inhalative exposure. Histopathological examination of the lungs of the animals that received inhalative exposure revealed haemorrhage, vascular congestion and oedema in the lungs and bronchopneumonia. The LC50-values for V2O3 (analytical grade, powder) is > 6.65 mg/L in female rats.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Oral Toxicity:
The test substance was suspended in 0.8 % aqueous hydroxypropyl-methyl-cellulose gel and administered by gavage. The volume of application was 20 ml/kg b.w.
Clinical Evaluation:
Following administration, observations were made and recorded systematically with individual records being maintained for each animal. Observations were performed immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration. Then twice daily for a period of 14 days. The time of death was recorded as precisely as possible. Individual body weights were recorded before administration of the substance, thereafter in weekly intervals up to the end of the study, and at death. At the end of the experiments all surviving animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded. Autopsy and macroscopic inspection of rats which died prematurely were carried out as soon as possible after exitus. - GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250g and 290g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 20 ml/kg b.w. - Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 218 mg/kg bw
- Based on:
- not specified
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 141 mg/kg bw
- Based on:
- not specified
- Sex:
- male
- Dose descriptor:
- other: No-effect level
- Effect level:
- 100 mg/kg bw
- Based on:
- not specified
- Sex:
- female
- Dose descriptor:
- other: No-effect level
- Effect level:
- 46.4 mg/kg bw
- Based on:
- not specified
- Mortality:
- Animals died up to 8 days after the oral exposure.
- Clinical signs:
- other: Following oral administration reduced motility, ataxia, muscular hypotonia, dyspnoea, reduced body weight gain and death were observed as toxic signs.
- Gross pathology:
- Macrosopic inspection revealed haemorrhagic intestinal mucosa and a dark liver following oral exposure in the animals that died prematurely.
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50 = 218 mg/kg bw(male rats), 141 mg/kg bw (female rats)
- Executive summary:
The acute oral toxicity of ammonium metavanadate (CAS 7803 -55 -6) was studies similar to OECD Guideline 401. Following administration, observations were made and recorded systematically with individual records being maintained for each animal. Observations were performed immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration. Then twice daily for a period of 14 days. The time of death was recorded as precisely as possible. Individual body weights were recorded before administration of the substance, thereafter in weekly intervals up to the end of the study, and at death. At the end of the experiments all surviving animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded. Autopsy and macroscopic inspection of rats which died prematurely were carried out as soon as possible after exitus. The LD50-values for the NH4VO3 test-substance (analytical grade, powder) following oral administration were 218 mg/kg bw for male and 141 mg/kg bw for female rats.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
- Limit test:
- no
- Specific details on test material used for the study:
- no details given
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250g and 290g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- > 2.01 - < 2.44 µm
- Remark on MMAD/GSD:
- An analysis of the particle size distribution was carried out twice during the exposure period using a cascade impactor according to May (May K. R. (1975) J. Aerosol. Sei. 6: 413).
The dust from the exposure chamber was sucked through the cascade impactor for 1.5 to 5 min at a constant flow rate of 5 l/min. The slides covered with adhesive tape were removed from the impactor and were weighted on an analytical balance (precision 10 µg). The mass median aerodynamic diameter (MMAD) was estimated by means of nonlinear regression analysis (Litchfield and Wilcoxon, (1949) J. Pharmacol. 95: 99). - Details on inhalation exposure:
- Analysis of the Dust Concentration:
The dust concentration in the inhalation chamber was measured with an air sample filter (Sartorius Minisart SM 17598). Dust samples were taken during the first half and during the second half of the exposure. For that purpose, Minisart SM 17598 filters were placed close to the animals' nose and sucked through with a constant flow of air of 300 l/h for 1 to 3 min. The filters were weighed before and after sampling. Concentration of the test substance in the air was calculated as mg/l. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- The study was carried out using a dynamic inhalation apparatus with a nose only exposure of the animals. The apparatus consists of a cylindrical exposure chamber (volume 40 l) which holds a maximum of 20 animals in pyrex tubes at the edge of the chamber in a radial position.
The dust was generated with a dust generator and dosing apparatus. The generator was fed with compressed air from a compressor. At the bottom of the exposure chamber the air was sucked off at a similar rate as created by the dust generator, in order to produce a homogeneous distribution in the exposure chamber. At least 12 air changes per hour were carried out. Air-flow meters were used to control the constant supply of compressed air and vacuum. Flow rates were checked at least once hour and corrected if necessary. Exposure time was 4 hours. - Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 11.09 mg/L air
- Based on:
- not specified
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 4.3 mg/L air
- Based on:
- not specified
- Sex:
- male
- Dose descriptor:
- other: No-effect level
- Effect level:
- 0.9 mg/L air
- Based on:
- not specified
- Sex:
- female
- Dose descriptor:
- other: No-effect level
- Effect level:
- 2.42 mg/L air
- Based on:
- not specified
- Mortality:
- Animals died up to 8 days after the inhalative exposure.
- Other findings:
- Histopathological examination of the lungs of the animals that received inhalative exposure revealed haemorrhage, vascular congestion and oedema in the lungs and bronchopneumonia
- Conclusions:
- LC50 = 11.09 mg/l (male rats), 4.3 mg/l (female rats)
- Executive summary:
Rats were exposed to dust of vanadium pentoxide (V2O5, CAS 1314 -62 -1) for 4 hours (nose only). Animals died up to 8 days after the inhalative exposure. Histopathological examination of the lungs of the animals that received inhalative exposure revealed haemorrhage, vascular congestion and oedema in the lungs and bronchopneumonia. The LC50-values for the V2O5 test-substance (analytical grade, powder) were 11.09 mg/L for male and 4.3 mg/L for female rats.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Oral Toxicity:
The test substance was suspended in 0.8 % aqueous hydroxypropyl-methyl-cellulose gel and administered by gavage. The volume of application was 20 ml/kg b.w.
Clinical Evaluation:
Following administration, observations were made and recorded systematically with individual records being maintained for each animal. Observations were performed immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration. Then twice daily for a period of 14 days. The time of death was recorded as precisely as possible. Individual body weights were recorded before administration of the substance, thereafter in weekly intervals up to the end of the study, and at death. At the end of the experiments all surviving animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded. Autopsy and macroscopic inspection of rats which died prematurely were carried out as soon as possible after exitus. - GLP compliance:
- not specified
- Limit test:
- no
- Specific details on test material used for the study:
- no details given
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250g and 290g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 ml/kg bw - Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- no details given
- Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 8 713 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 639 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- other: No-effect level
- Effect level:
- 4 640 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- other: No-effect level
- Effect level:
- 4 640 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Animals died up to 8 days after the oral exposure.
- Clinical signs:
- other: Following oral administration reduced motility, ataxia, muscular hypotonia, dyspnoea, reduced body weight gain and death were observed as toxic signs.
- Gross pathology:
- Macrosopic inspection revealed haemorrhagic intestinal mucosa and a dark liver following oral exposure in the animals that died prematurely.
- Conclusions:
- LD50 = 8713 mg/kg (male rats), 5639 mg/kg (female rats)
- Executive summary:
The acute oral toxicity of vanadium (III) oxide (CAS 1314 -34 -7) was studies similar to OECD Guideline 401. Following administration, observations were made and recorded systematically with individual records being maintained for each animal. Observations were performed immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration. Then twice daily for a period of 14 days. The time of death was recorded as precisely as possible. Individual body weights were recorded before administration of the substance, thereafter in weekly intervals up to the end of the study, and at death. At the end of the experiments all surviving animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded. Autopsy and macroscopic inspection of rats which died prematurely were carried out as soon as possible after exitus.
The LD50-values for the V2O3 test-substance (analytical grade, powder) following oral administration were 8713 mg/kg for male and 5639 mg/kg for female rats.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250 g and 290 g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
- Type of coverage:
- occlusive
- Vehicle:
- other: 0.8% aqueous hydroxypropyl-methyl-cellulose gel
- Details on dermal exposure:
- The hair on the site of application was clipped with hair-clippers, without causing injury, approximately 24 hours before application.
The site was situated on the animal's back between the fore and hind extremitites and had an area of approx. 5 x 6 cm (=1/10 body surface).
The test substance was applied to 8 layers of gauze and then to the application site. The patch was covered with a plastic sheet and secured with adhesive plaster. - Duration of exposure:
- 24 hours
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration; then twice daily for a period of 14 days
- Frequency of body weights: before administration, then weekly for a period of 14 days
- Necropsy of survivors performed: yes - Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
- Preliminary study:
- not performed
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- other: no-effect level
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no signs of toxicity were observed
- Mortality:
- Mortality did not occur in treated animals.
- Clinical signs:
- other: No signs of toxicity were observed following dermal application.
- Gross pathology:
- not performed
- Other findings:
- No signs of toxicity were observed following dermal application.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No mortality occurred at a tested level of 2500 mg/kg bw. The LD50 is considered to be more than 2500 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study (limit test similar to OECD Guideline 402), groups of Sprague-Dawley rats (5/group) were given a single dermal dose of ammonium metavanadate, at 2500 mg/kg bw and observed for 14 days. No mortality occurred in this test; therefore an exact LD50 has not been determined. The test article, when administered dermally as received to 5 Sprague Dawley rats had an acute dermal LD50 of greater than 2.5 g/kg bw. No evidence of systemic toxicity was observed.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- no details given
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250 g and 290 g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
- Type of coverage:
- occlusive
- Vehicle:
- other: 0.8% aqueous hydroxypropyl-methyl-cellulose gel
- Details on dermal exposure:
- The hair on the site of application was clipped with hair-clippers, without causing injury, approximately 24 hours before application.
The site was situated on the animal's back between the fore and hind extremities and had an area of approx. 5 x 6 cm (=1/10 body surface).
The test substance was applied to 8 layers of gauze and then to the application site. The patch was covered with a plastic sheet and secured with adhesive plaster. - Duration of exposure:
- 24 hours
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration; then twice daily for a period of 14 days
- Frequency of body weights: before administration, then weekly for a period of 14 days
- Necropsy of survivors performed: yes - Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
- Preliminary study:
- not performed
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- other: no-effect level
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no signs of toxicity were observed
- Mortality:
- Mortality did not occur in treated animals.
- Clinical signs:
- other: No signs of toxicity were observed following dermal application.
- Gross pathology:
- not performed
- Other findings:
- No signs of toxicity were observed following dermal application.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No mortality occurred at a tested level of 2500 mg/kg bw. The LD50 is considered to be > 2500 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study (limit test similar to OECD Guideline 402), groups of Sprague-Dawley rats (5/group) were given a single dermal dose of vanadium pentoxide, at 2500 mg/kg bw and observed for 14 days. No mortality occurred in this test; therefore an exact LD50 has not been determined. The test article vanadium pentoxide, when administered dermally as received to 5 Sprague Dawley rats had an acute dermal LD50 of greater than 2.5 g/kg bw. No evidence of systemic toxicity was observed.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Vanadium and its inorganic compounds (inhalable fraction)
- Year:
- 2 009
- Bibliographic source:
- The MAK-Collection Part I: MAK Value Documentations, Vol. 25. DFG, Deutsche Forschungsgemeinschaft
- Reference Type:
- publication
- Title:
- New Investigations on Acute Toxicities of Vanadium Oxides
- Author:
- J. Leuschner et al.
- Year:
- 1 994
- Bibliographic source:
- Monatshefte für Chemie 125. 623-646
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Oral Toxicity:
The test substance was suspended in 0.8 % aqueous hydroxypropyl-methyl-cellulose gel and administered by gavage. The volume of application was 20 ml/kg b.w.
Clinical Evaluation:
Following administration, observations were made and recorded systematically with individual records being maintained for each animal. Observations were performed immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration. Then twice daily for a period of 14 days. The time of death was recorded as precisely as possible. Individual body weights were recorded before administration of the substance, thereafter in weekly intervals up to the end of the study, and at death. At the end of the experiments all surviving animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded. Autopsy and macroscopic inspection of rats which died prematurely were carried out as soon as possible after exitus. - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Divanadium pentaoxide
- EC Number:
- 215-239-8
- EC Name:
- Divanadium pentaoxide
- Cas Number:
- 1314-62-1
- Molecular formula:
- O5V2
- IUPAC Name:
- dioxovanadiooxy(dioxo)vanadium
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- no details given
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals used were Sprague Dawley rats (Lippische Versuchstierzucht Hagemann GmbH. Extertal, Germany) weighing between 250g and 290g. Rats were provided with standard rat diet and water ad libitum. The diet was withdrawn approx. 16 hours before application. At the onset of the main experiment animals were randomly divided into group of 5.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 ml/kg bw - Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- no details given
- Statistics:
- The LD50 was calculated according to Finney D.J., Probit Analysis, 3rd Edition, Cambridge University Press, Cambridge, 1971
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 470 mg/kg bw
- Based on:
- not specified
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 467 mg/kg bw
- Based on:
- not specified
- Sex:
- male
- Dose descriptor:
- other: No-effect level
- Effect level:
- 215 mg/kg bw
- Based on:
- not specified
- Sex:
- female
- Dose descriptor:
- other: No-effect level
- Effect level:
- 215 mg/kg bw
- Based on:
- not specified
- Mortality:
- Animals died up to 8 days after the oral exposure.
- Clinical signs:
- other: Following oral administration reduced motility, ataxia, muscular hypotonia, dyspnoea, reduced body weight gain and death were observed as toxic signs.
- Gross pathology:
- Macrosopic inspection revealed haemorrhagic intestinal mucosa and a dark liver following oral exposure in the animals that died prematurely.
Applicant's summary and conclusion
- Conclusions:
- LD50 = 470 mg/kg (male rats), 467 mg/kg (female rats)
- Executive summary:
The acute oral toxicity of vanadium pentoxide (CAS 1314 -62 -1) was studies similar to OECD Guideline 401. Following administration, observations were made and recorded systematically with individual records being maintained for each animal. Observations were performed immediately, 5, 15, 30 and 60 min, as well as 3 h, 6 h and 24 h after administration. Then twice daily for a period of 14 days. The time of death was recorded as precisely as possible. Individual body weights were recorded before administration of the substance, thereafter in weekly intervals up to the end of the study, and at death. At the end of the experiments all surviving animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded. Autopsy and macroscopic inspection of rats which died prematurely were carried out as soon as possible after exitus.The LD50-values for the V2O5 test-substance (analytical grade, powder) following oral administration were 470 mg/kg for male and 467 mg/kg for female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)