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EC number: 236-759-1 | CAS number: 13476-99-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The parent compound Vanadium-tris-acetylacetonate is rapidly hydrolysed to 2,4 -pentanedione (CAS no. 123 -54- 6) and Vanadyl acetylacetonate (CAS no. 3153 -26 -2) in the presence of water or moisture (> 80% hydrolysis after 1h at pH 1.2, 4, 7 and 9). Hence, the half life is < 1 h under neutral and acidic conditions. Accordingly, reliable data of the hydrolysis products 2,4-Pentadione (Cas no. 123-54-6) and Vanadyl acetylacetonate (3153-26-2) or comparable inorganic Vanadium compounds are used to address the endpoint, which is entirely appropriate to draw conclusions on the potential of Vanadium-tris-acetylacetonate to cause irritation or corrosion to the skin or eyes of mammals.
skin irritation
Acetylacetonate, rabbit, 0.5 mL (undiluted), 4 h, occlusive, 14 d (OECD TG 404): mild skin irritating
eye irritation
Acetylacetonate, rabbit, 0.1 mL (undiluted), 4 h, occlusive, 7 d (OECD TG 405): mild eye irritating
V2O5 microparticles, estimated 0.5 mg/m3 air, human: eye irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- please refer to Read-across statement attached in section 13
- Reason / purpose for cross-reference:
- read-across source
- Remarks on result:
- probability of mild irritation
- Remarks:
- see section "any other information on results incl. tables"
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Exposure to the test substance acetylacetonate caused very slight local erythema and mild or moderate edema in all 6 animals. Effects were reversible apart from desquamation visible after 7 days. Therefore, this study indicates a mild skin irritating potential of acetylacetonate. This result is also valid for the target substance vanadium-tris-acetylacetonate, since the source substance acetylacetonate is a hydrolysis product of vanadium-tris-acetylacetonate.
- Executive summary:
The primary dermal irritation potential of acetylacetonate was evaluated in this study with New Zealand White rabbits similar to OECD Guideline 404. There was one group of six albino rabbits that received a single, 4 hour, occluded exposure. Each 0.5 mL dose of the acetylacetonate test article was applied to the clipped dorsal skin. At completion of exposure, the bandages were removed and the excess test item removed gently. Application sites were evaluated in accordance with the method of Draize at 1 , 24, 48 and 72 hours, 7 and 14 days after patch removal. Very slight local erythema and mild or moderate edema were noted for all animals. Effects were reversible apart from desquamation visible after 7 days. Therefore, this study indicates a mild skin irritating potential of acetylacetonate. However, the observed erythema and edema scores do not meet the requirements for classification as laid down in Regulation (EC) No 1272/2008. This result is also valid for the target substance vanadium-tris-acetylacetonate, since the source substance acetylacetonate is a hydrolysis product of vanadium-tris-acetylacetonate.
Reference
Erythema:
- very slight local erythema in 5 of 6 rabbits on removal of the occlusive dressing (corresp. to score 1)
- very slight local erythema in 6 of 6 rabbits after 24 h (corresp. to score 1)
Edema:
- slight in 5 of 6 rabbits (corresp. to score 2)
- moderate in 1 of 6 rabbits (corresp. to score 3)
Reversibility:
- after 3 days, half the animals had just detectable erythema, one animal had mild edema
- after 7 days, mild desquamation (no other effects were seen)
Table 2. Scores for erythema and edema for various epicutaneous dosages o f 2.4-PD
Inspection Day |
244 mg/kg |
975mg/kg |
1463mg/kg |
|||
Males |
Females |
Males |
Females |
Males |
Females |
|
ERYTHEMA |
||||||
1 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0.2(0-1) |
0 |
0 |
0 |
4 |
0 |
0 |
0 |
0.3(0-1) |
0.3(0-1) |
0.5 (0-1) |
5 |
0 |
0 |
0.6(0-2) |
1.3(1-2) |
2.0(All2) |
1.7 (1-2) |
6 |
0 |
0.3 (0-1) |
1.0(0-2) |
1.3(1-2) |
1.8 (1-2) |
1.7 (1-2) |
7 |
0 |
0.3 (0-1) |
1.0(0-2) |
1.3 (1-2) |
1.8 (1-2) |
1.7 (1-1) |
8 |
0.5(0-1) |
0.5 (0-1) |
1.4(1-2) |
1.7 (1-2) |
1.5 (1-2) |
2.0(All2) |
9 |
0.5(0-1) |
1.0(All1) |
1.8(1-2) |
1.7 (1-2) |
1.3 (1-2) |
2.0(All2) |
10 |
0.5(0-1 ) |
1.0(All1) |
1.4(0-2) |
1.3 (1-2) |
1.3 (1-2) |
1.0(AII1) |
11 |
0.2(0-1) |
1.0(All1) |
1.0(0-2) |
1.0(All 1) |
1.3(1-2) |
1.0(All1) |
12 |
0.3 (0-1 ) |
1.0(All1) |
0.8(0-2) |
1.0(AII1) |
1.3 (1-2) |
1.0(All1) |
EDEMA |
||||||
1 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0.3(0-1) |
4 |
0 |
0 |
0 |
0.3(0-1) |
0.5(0-1) |
0.6(0-1) |
5 |
0 |
0 |
1.2 (0-2) |
1.0(All1) |
1.8 (1-2) |
1.7 (1-2) |
6 |
0 |
0 |
1.2(0-2) |
1.0 (AII1) |
1.5(1-2) |
1.7 (1-2) |
7 |
0 |
0 |
1.2 (0-2) |
1.0(AII1) |
1.5(1-2) |
1.7 (1-3) |
8 |
0.5 (0-2) |
0.3 (0-1) |
1.8(1-3) |
1.3 (1-2) |
2.5 ( 2 3) |
2.0(All2) |
9 |
0.7 (0-2) |
0.5 (0-1) |
2.0(1-3) |
1.3 (1-2) |
2-5(2-3) |
2.0(All2) |
10 |
0.7 (0-2) |
0.8(0-1) |
2.0(1-3) |
1.3(1-2) |
2-5 (2-3) |
2.0(All2) |
11 |
0.8 (0-2) |
1.0 (0-2) |
1.8(1-3) |
1.3 (1-2) |
2.5 (2 -3) |
2.0(All 2) |
12 |
1.0(0 -2) |
1.2 (0-2) |
1.6(1-3) |
1.3 (1-2) |
2.5 (2-3) |
2.0(All2) |
a No effects seen in control (water) group,
b Scored as: 0 = no effect, 1 = barely perceptible, 2 = well defined, 3 = moderate, 4 = severe
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- please refer to Read-across statement attached in section 13
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 0.2
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 0.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0.8
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Mean scores at 1 and 4 hours for conjunctival redness and iritis were 0-1 in all animals. Mean scores at 1 and 4 hours for each animal for chemosis and discharge was 0-2 for all animals. Effects were fully reversible, as no effects were seen after 24 h.
Therefore, the acetylacetonate test substance is minimal irritating to rabbit eyes. This result is also valid for the target substance vanadium-tris-acetylacetonate, since the source substance acetylacetonate is a hydrolysis product of vanadium-tris-acetylacetonate. - Executive summary:
In this study, the eye irritation potential of the acetylacetonate test substance was evaluated similar to OECD Guideline 405. A group of six albino rabbits was used for the study. Each animal received a single, unwashed exposure of 0.1 mL of the test article instilled into the lower conjunctival sac of one eye. The eyelid was held closed for one second and released. Observations for eye irritation were made at 1, 4, and 24 hours following dosing and on days 2, 3, and 7.
Mean scores at 1 and 4 hours for conjunctival redness and iritis were 0-1 in all animals. Mean scores at 1 and 4 hours for each animal for chemosis and discharge was 0-2 for all animals. Effects were fully reversible, as no effects were seen after 24 h.
Therefore, the acetylacetonate test substance is minimal irritating to rabbit eyes, but it does not meet the criteria for classification as laid down in Regulation (EC) No 1272/2008.
This result is also valid for the target substance vanadium-tris-acetylacetonate, since the source substance acetylacetonate is a hydrolysis product of vanadium-tris-acetylacetonate.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- please refer to Read-across statement attached in section 13
- Reason / purpose for cross-reference:
- read-across source
- Remarks on result:
- positive indication of irritation
- Remarks:
- eye irritation (conjunctivitis) was observed in 16 of 18 exposed man
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Vanadium pentoxide microparticles caused eye irritation in 16 of 18 workers acutely exposed to vanadium pentoxide microparticles.
- Executive summary:
Eighteen workers became were exposed to high concentrations (estimated 0.5 mg/m3 air) vanadium pentoxide particles of small particle size (0.1 and 10 µm). Vanadium pentoxide microparticles caused eye irritation in 16 of 18 workers. This indicates that the vanadium compound formed as a hydrolysis product of the target substance vanadium-tris-acetylacetonate may be eye irritating.
Referenceopen allclose all
Effects (scores see table below):
Conjunctivae: just detectable excess conjunctival redness in 5 of 6 animals at 1 h postinstallation
Chemosis: slight chemosis in 2 of 6 animals, moderate chemosis in 1 of 6 animals
Iritis: mild iritis in 2 of 6 animals, persisting up to 4 h
Scores for the various effects seen in rabbit eyes following the installation of 0.1 mL acetylacetonate into the inferior conjunctival sac of one eye of each of six rabbits (scored according to the system of Draize):
Time |
Effect as average (and range) |
|||
|
Conjunctiva |
Iris |
||
|
Redness |
Chemosis |
Discharge |
|
1 h |
0.8 (0-1) |
0.7 (0-2) |
1.3 (0-2) |
0.3 (0-1) |
4 h |
0.7 (0-1) |
0.7 (0-2) |
1.2 (0-2) |
0.2 (0-1) |
24 h |
0.0 |
0.0 |
0.0 |
0.0 |
Reversibility: All eyes were healed by 24 h postinstallation. No evidence of corneal injury on macroscopic inspection or following the installation of 2% fluorescein.
Three of the men exposed most severely had the symptom of 'burning eyes' after the first day of exposure. Upon examination after three days a slight conjunctivitis was diagnosed in these three workers. After two weeks of exposure to vanadium pentoxide particles, conjunctivitis was observed in 16 of 18 workers.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
skin irritation
The primary dermal irritation potential of acetylacetonate was evaluated in a study with New Zealand White rabbits similar to OECD Guideline 404. There was one group of six albino rabbits that received a single, 4 hour, occluded exposure. Each 0.5 mL dose of the acetylacetonate test article was applied to the clipped dorsal skin. At completion of exposure, the bandages were removed and the excess test item removed gently. Application sites were evaluated in accordance with the method of Draize at 1, 24, 48 and 72 hours, 7 and 14 days after patch removal. Very slight local erythema and mild or moderate edema were noted for all animals. Effects were reversible apart from desquamation visible after 7 days. Therefore, this study indicates a mild skin irritating potential of acetylacetonate.
For the vanadium containing source substances this endpoint is waived based on acute dermal toxicity studies. Here, no toxic effects were observed for V2O5, V2O3 and NH4VO3 at a concentrations of 2500 mg/kg bw. This waiver is supported by a patch test study in humans. In this study 100 humans were patch tested with vanadium pentoxide at the concentrations 1, 2 and 10 %. No skin reactions were observed (Motolese 1993).
eye irritation
The eye irritation potential of the acetylacetonate test substance was evaluated in accordance with OECD Guideline 405. A group of six albino rabbits was used for the study. Each animal received a single, unwashed exposure of 0.1 mL of the test article instilled into the lower conjunctival sac of one eye. The eyelid was held closed for one second and released. Observations for eye irritation were made at 1, 4, and 24 hours following dosing and on days 2, 3, and 7. Mean scores at 1 and 4 hours for conjunctival redness and iritis were 0-1 in all animals. Mean scores at 1 and 4 hours for each animal for chemosis and discharge was 0-2 for all animals. Effects were fully reversible, as no effects were seen after 24 h. Therefore, the acetylacetonate test substance is minimal irritating to rabbit eyes (Ballantyne 1986).
For vanadium compounds human data from an accident are available: Eighteen workers were exposed to high concentrations (estimated 0.5 mg/m3 air) vanadium pentoxide particles of small particle size (0.1 and 10 µm). Vanadium pentoxide microparticles caused eye irritation in 16 of 18 workers (Zenz 1962), please refer also to section 7.10.3.
respiratory irritation
In several studies with vanadium pentaoxide on acute inhalation toxicity irritating effects on the respiratory tract were reported.
Rats were exposed to dust of vanadium pentoxide (V2O5, CAS 1314 -62 -1) for 4 hours (nose only). Animals died up to 8 days after the inhalative exposure. Histopathological examination of the lungs of the animals that received inhalative exposure revealed haemorrhage, vascular congestion and oedema in the lungs and bronchopneumonia.
This finding is also supported by findings in humans from an accidenal exposure (Zenze, 1986). Eighteen workers became acutely ill following inhalation of high concentrations (estimated 0.5 mg/m3 air) vanadium pentoxide particles of small particle size (0.1 and 10 µm). The clinical signs were irritation of the upper and lower respiratory tract, nasopharyngitis, hacking cough, fine rales and wheezing, bronchospastic, eye irritation (conjunctivitis), clinical illness. The onset and severity of symptoms equated directly with the intensity of exposure. The symptoms due to a second exposure were of greater intensity than those following the first exposure. The detection of vanadum in the urine indicates systemic absorption of vanadium after the inhalatory exposure.
Justification for classification or non-classification
Based on the available data on the source substance vanadium pentoxide, the target substance vanadium-tris-acetylacetonate is classified as eye irritant (Category 2, H319) and irritant to the respiratoty tract (H335) in accordance with Regulation (EC) No 1272/2008. Regarding skin irritation, the observed erythema and edema scores in rabbits after 2,4 -pentanedione application do not meet the requirements for classification as laid down in Regulation (EC) No 1272/2008.
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