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EC number: 214-317-9 | CAS number: 1120-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May/June 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study performed in compliance with the UK Principles of Good Laboratory Practice
- Justification for type of information:
- The target substance 1,3-propanesultone hydrolyses rapidly. The product of hydrolysis is the source substance 3-hydroxypropanesulphonic acid.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Mixed population of sewage treatment micro-organisms from the secondary treatment stage of the Severn Trent water Plc sewage treatment plant at Belper, Derbyshire, UK
- Pretreatment: the effluent was filtered (Postlip filter paper and maintanied at 21°C prior to use. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 40 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Test temperature: 24°C
- pH: >6
- pH adjusted: yes if neccessary to pH 7.4 with sodium hydroxide or sulphuric acid solutions
- Suspended solids concentration: 0.5 ml/L
- Continuous darkness: yes
TEST SYSTEM
- Number of culture flasks/concentration: 2
- Measuring equipment: DOC was measred using a Dohrmann DC-190 TOc analyser.
SAMPLING
- Sampling frequency: on day 1, 2, 3, 6, 8, 10, 14, 16, 21, 23, 27 and 28
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 89
- Sampling time:
- 28 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 86
- Sampling time:
- 10 d
- Results with reference substance:
- Degradation rate: 97% after 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- no
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- according to MITI specifications
- Duration of test (contact time):
- ca. 4 wk
- Initial conc.:
- ca. 100 mg/L
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- TOC removal
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Details on study design:
- TEST CONDITIONS
Concentration of activated sludge : 30 mg/L - Parameter:
- % degradation (O2 consumption)
- Value:
- 95
- Sampling time:
- 28 d
- Remarks on result:
- other: BOD
- Parameter:
- % degradation (TOC removal)
- Value:
- 81
- Sampling time:
- 28 d
- Parameter:
- % degradation (test mat. analysis)
- Remarks:
- IC
- Value:
- 100
- Sampling time:
- 28 d
- Remarks on result:
- other: Calculated based on the theoretical amount of 3-Hydroxypropane-1-sulfonic acid.
- Interpretation of results:
- readily biodegradable
Referenceopen allclose all
Biodegradation rate of 3 -Hydroxypropanesulphonic acid
Day | % Degradation |
1 | 3 |
2 | 19 |
3 | 13 |
6 | 82 |
8 | 83 |
10 | 86 |
14 | 84 |
16 | 85 |
21 | 89 |
23 | 91 |
27 | 90 |
28 | 89 |
The test substance was rapidly hydrolyzed in water and generated 3-Hydroxypropane-1-sulfonic acid. After 28 days, the 3-Hydroxypropane-1-sulfonic acid was not detected in both of (water + test substance) system and ( sludge + test substance) system, and unknown peak which was thought to be transformation product was detected.
Description of key information
The parent substance 1,3 propansultone and the product of hydrolysis, 3-hydroxypropanesulphonic acid, are readily biodegradable according to OECD criteria.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
On contact with water the substance 1,3-propanesultone rapidly hydrolyses forming 3-hydroxypropanesulphonic acid. Therefore the assessment of biodegradation is based on the product of hydrolysis.
The ready biodegradability of 3-hydroxypropanesulphonic acid was investigated in a GLP study conducted according to OECD Guideline 301 E. At the end of the test period (28 d) the biodegradation of the test substance reached 89% and the level was reached within the 10-day window criteria. 3-hydroxypropanesulphonic acid can be therefore considered to be readily biodegradable.
A study on 1,3-propanesultone conducted according to OECD 301C a degradation rate of 95% based on O2 consumption was determined after 28 days (81% TOC removal after 28 d). A rapid hydrolysis was observed in the test. After 28 days, the 3-Hydroxypropane-1-sulfonic acid was not detected in both of (water + test substance) system and (sludge + test substance) system, and an unknown peak, assumed to be the transformation product, was detected.
Slightly divergent results were obtained by a further study on the ready biodegradability of the parent substance 1,3-propanesultone. The test followed the biodegradation according to the modified OECD screening test (OECD 301E). After 28 days a degradation rate of 64% was determined. The positive control substance (sodium benzoate) was 100 % degraded after 28 days. The degradation was not a linear process since the biodegradation observed after 14 days (26.7%) was markedly lower than the level reached after 7 days (46%).
Conclusion
The product of hydrolysis, 3-hydroxypropanesulphonic acid and the parent substance, 1,3-propanesultone are considered readily biodegradable according to OECD criteria.
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