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Diss Factsheets
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EC number: 214-317-9 | CAS number: 1120-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- THE CARCINOGENIC RESPONSE IN MICE TO THE TOPICAL APPLICATION OF PROPANE SULTONE TO THE SKIN
- Author:
- Doak, S.M.A. et al.
- Year:
- 1 976
- Bibliographic source:
- Toxicology 6, 139-154
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- -The test solutions and solvents were applied to the skin with fine brushes (one application of 25% w/v propane sultone in toluene)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-propanesultone
- EC Number:
- 214-317-9
- EC Name:
- 1,3-propanesultone
- Cas Number:
- 1120-71-4
- Molecular formula:
- C3H6O3S
- IUPAC Name:
- 1,2λ⁶-oxathiolane-2,2-dione
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: CFI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - mice were bred in specific pathogen- free conditions at Tunstall Laboratory
- six weeks of age at the beginning of treatment
- water and cubed 86S diet (obtained from Grain Harvesters, Wingham, Kent) were provided ad libitum
- mice were individually housed
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: toluene
- Details on dermal exposure:
- - the hair on the back was shorn with fine electric clippers before treatment started
- the test solution (0.1 mL) was applied to the dorsal skin using all-glass syringes - Duration of exposure:
- - one single application
- Doses:
- - 25% (w/v) = 25 mg/mouse corresp. to 830 mg/kg bw
- No. of animals per sex per dose:
- - 48
- Control animals:
- yes
- Details on study design:
- The occurence of lethality was observed daily.
Each animal was examined weekly and the size, appearance and position of all skin lesions were recorded.
After 78 weeks, the mice were killed and subjected to a detailed necropsy and a histological examination of skin and the major viscera for the presence of neoplasms. Similar examinations were carried out on animals dying or killed because of ill-health during the experiment, with the exception of those not surviving beyond the first 7 days after exposure.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: LD15
- Effect level:
- 830 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: - during the first 4 days of the study, 12 males and 2 females died (group size: 48 mice each)
- Mortality:
- - 12 males and 2 females died after 4 days
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
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