Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 205-599-4 | CAS number: 143-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The conduct of skin sensitisation studies according to established protocols is not feasible, as dermally applied solutions of cyanide salts would result in high acute systemic toxicity before immunologic sensitisation occurs. Risk management measures, including gloves and other barriers, as dictated by classification according to Annex VI of Regulation (EC) 1272/2008, will protect against sensitisation as well as acute toxicity effects and irritation.
Migrated from Short description of key information:
The systemic toxicity of cyanides is sufficiently high that systemic intoxication and death are likely to occur before the development of inflammatory sensitisation effects on the skin
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No information is available concerning respiratory sensitisation. While respiratory sensitisation can not be excluded especially with solution, appropriate measures have to be applied to avoid inhalation of the substances, due to the high systemic potential. Risk management measures, including local exhaust ventilation and respirators are dictated by the classification in Annex VI of Regulation (EC) 1272/2000, and will protect against both acute inhalation toxicity and respiratory sensitisation.
Migrated from Short description of key information:
While respiratory sensitisation can not be excluded, especially with solutions of NaCN, appropriate measures have to be implemented to avoid inhalation of the offending substances.
Justification for classification or non-classification
There is insufficient evidence to classify cyanide salts as dermal or respiratory sensitisers. The listing of cyanide salts in Annex VI of Regulation (EC) No. 1272/2008 does not indicate that cyanide salts are sensitisers. The systemic toxicity of cyanides is sufficiently high that systemic intoxication and death are likely to occur before the development of immune effects in the skin or lung. The risk management measures designed to protect against acute systemic toxicity will also protect against sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.