Plastic, waste, pyrolized, fractionation bottoms

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

Not applicable, calculated value

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Remarks:

This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this substance.

Justification for type of information:

Petrotox is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

The aquatic toxicity was estimated by a QSAR. the PETROTOX computer model (version 3.06). This model combined a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculation acute and chronic toxicity of non-polar narcotic chemicals. PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

GLP compliance:

no

Analytical monitoring:

not required

Test organisms (species):

Daphnia magna

Test type:

other: QSAR

Water media type:

freshwater

Limit test:

no

Total exposure duration:

21 d

Key result

Duration:

21 d

Dose descriptor:

other: NOEL

Effect conc.:

ca. 1.86 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat. (dissolved fraction)

Basis for effect:

not specified

Validity criteria fulfilled:

yes

Conclusions:

The QSAR model predicts the NOEC of the substance to invertebrates (dfaphnia magna) to be 1.86 mg/L.

Executive summary:

 Results of computer modelling to estimate aquatic chronic toxicity in a 21-day freshwater invertebrates study show that the PETROTOX model (version 3.06) predicted the NOEC of the substance for Daphnia magnao to be 1.86 mg/L

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Dose descriptor:

NOEC

Effect concentration:

ca. 1.86 mg/L