Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-109-3 | CAS number: 103-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other: unpublished report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- The acute dermal toxicity of the test substance was tested in rabbits. The test material was applied once to the clipped backs of the animals, on both abraded and intact clipped skin areas, at dose levels of 1, 2 or 3 g/kg bw, under occlusive coverage for a period of 24 hours. After the exposure period of 24 hours the skin reactions were recorded and the animals were observed for signs of toxicity for the following 14 days.
- GLP compliance:
- no
- Remarks:
- test carried out pre-GLP-guideline
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzyl cinnamate
- EC Number:
- 203-109-3
- EC Name:
- Benzyl cinnamate
- Cas Number:
- 103-41-3
- Molecular formula:
- C16H14O2
- IUPAC Name:
- benzyl 3-phenylacrylate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2-3 kg
- Diet (e.g. ad libitum): daily ration pellets
- Water (e.g. ad libitum): daily ration water
- Acclimation period: at least 2 weeks; hematology (red and white cell count, differential, grams hemoglobin, % hematocrit) and urinalysis was performed (on each animal), and eating habits and general appearance were observed.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST SITE
- Back: clipped free of all hair; epidermal longitudinally abrasions every 2-3 cm (penetrated stratum corneum but not dermis (no bleeding)
- Area of exposure: clipped intact and abraded skin areas
- Type of wrap: rubber sleeve or dam
- time exposure: 24 hours
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes after 24 hours
TEST MATERIAL
- Concentration (if solution): 500 mg/mL
- Dose levels: 2 mL/kg bw (1 g active/kg), 4mL/kg bw (2g active/kg), 6mL/kg bw (3 g active/kg)
- For solids, paste formed: no - Duration of exposure:
- 24 hours
- Doses:
- 2 mL/kg bw (1 g/kg bw), 4 mL/kg bw (2 g/kg bw), 6 mL/kg bw (3 g/kg bw)
- No. of animals per sex per dose:
- 4 animals in total per dose, no information on sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Observations and weighing: body weights, general behaviour, food consumption
- Necropsy of survivors performed: no
- Other examinations performed: haematology and urinalysis
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- Moderate erythema, fully reversible within 48 hours.
- Body weight:
- The animals consumed their daily ration and gained weight and behaved as normal laboratory acclimated animals.
- Gross pathology:
- Comparison of their initial and final hematological values did not reveal any significant changes.
Any other information on results incl. tables
Examination of the treated backs after 24 hours showed moderate erythema but no edema or eschar formation and 24 hours later the treated backs showed a decrease in the degree of erythema. 48 hours after exposure the treated backs were normal.
Body weight:
|
Body weight (kg) |
|
|
Initial |
Final |
2.0 mL/kg bw (1 g/kg bw) |
||
Rabbit 1 |
2.6 |
2.8 |
Rabbit 2 |
2.5 |
2.9 |
Rabbit 3 |
2.7 |
2.8 |
Rabbit 4 |
3.0 |
3.1 |
4.0 mL/kg bw (2 g/kg bw) |
||
Rabbit 5 |
3.0 |
3.2 |
Rabbit 6 |
3.0 |
3.1 |
Rabbit 7 |
2.7 |
2.8 |
Rabbit 8 |
2.8 |
3.0 |
6.0 mL/kg bw (3 g/kg bw) |
||
Rabbit 9 |
3.0 |
3.2 |
Rabbit 10 |
3.0 |
3.1 |
Rabbit 11 |
2.6 |
2.9 |
Rabbit 12 |
2.6 |
2.7 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- The test item did not induce acute toxicity via the dermal route in rabbits up to a dose of 3000 mg/kg bw.
- Executive summary:
In this study the acute dermal toxicity of the test substance was tested in rabbits. No guideline was followed and the study was not according to GLP.
The test material was applied once to the clipped backs of the animals, on both abraded and intact clipped skin areas. The dose levels were 1, 2 or 3 g/kg bw. The animals were covered with a rubber sleeve which fit snuggle around the animal. The animals were placed in an animal holder and exposed for a period of 24 hours.
After the exposure period of 24 hours, the rubber sleeves were removed and the skin reactions were recorded. Each animal was thoroughly wiped down and returned to its own metabolism cage to be observed for the following 14 days.
Examination of the treated backs after 24 hours showed moderate erythema but no edema or eschar formation and 24 hours later the treated backs showed a decrease in the degree of erythema. 48 hours after exposure the treated backs were normal.
The animals consumed their daily ration, gained weight and behaved normal. No animals died during the test and the animals did not show any toxicity signs, nor any significant differences between their initial and final hematogram. From these data an LD50 > 3000 mg/kg bw can be deduced.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.