Bis(2-chloroethyl) ether

Partition coefficient

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Version / remarks:

The method is described in Fujita, Iwasa & Hansch (1964) J. Am. Chem. Soc., 86:5175

Deviations:

yes

Remarks:

Some methodological details are not reported (volume of the two phases, concentration of test substance, unclear if both phases have been analyzed)

GLP compliance:

not specified

Type of method:

flask method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

TEST MATERIAL
- Name (as cited): Bis(2-chloroethyl) ether
- Purity: not specified

Analytical method:

photometric method

Key result

Type:

log Pow

Partition coefficient:

1.12

Temp.:

20 °C

Remarks on result:

other: pH not specified

Conclusions:

The Log Pow of Bis(2-chloroethyl) ether was determined to be 1.12.

Executive summary:

In a publication by Veith et al. (1980), experimental data on the estimation of the partition coefficient of Bis(2-chloroethyl) ether are reported. The methodology used is similar to OECD Guideline No. 107 and the publication has been subject to peer-review. The data is thus considered reliable and has been assigned a reliability score of 2. The Log Pow of Bis(2-chloroethyl) ether was determined to be 1.12.

Reference 2

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

yes

Remarks:

The concentration of test substance was analyzed only in one phase. Measurement perfomed at "room temperature".

Type of method:

flask method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

Test material (as cited): Bis(2-chloroethyl) ether
Purity: not specified

Analytical method:

other: Not specified

Type:

log Pow

Partition coefficient:

1.58

Conclusions:

Based on a shake-flask method, the Log Pow of Bis(2-chloroethyl) ether was determined to be 1.58.

Executive summary:

In a review on partition coeffcients and their uses published by Leo et al. (1971), experimental data on the partition coefficient of Bis(2-chloroethyl) ether are reported. The data was generated based on a shake-flask method, but no extra methodological details are provided. The Log Pow of Bis(2-chloroethyl) ether was determined to be 1.58.

Reference 3

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Qualifier:

no guideline followed

Principles of method if other than guideline:

- Principle of test: calculation mtehod
- Short description of test conditions: not available

Type of method:

other: calculation method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

Test material (as cited): Bis(2-chloroethyl) ether
Purity: not specified

Analytical method:

not specified

Type:

log Pow

Partition coefficient:

1.48

Type:

Pow

Partition coefficient:

29

Conclusions:

The Kow of Bis(2-chloroethyl) ether is reported to be 29.

Executive summary:

A Kow value equal to 29 is reported for Bis(2-chloroethyl) ether in this collection of data published by US EPA. U.S. EPA reports are subjected to a formal review process. It is thus assumed that a variety of data sources have been consulted, that the test methodology and identity of the test substance has been evaluated, and that a reliable and representative value for the endpoint has been selected. Accordingly, this data was assigned a reliability score of 2.

Description of key information

Based on the results of a detailed study using a methodology similar to OECD Guideline No. 107 (shake-flask method), the Log Pow of Bis(2-chloroethyl) ether was found to be equal to 1.12.

Key value for chemical safety assessment

Log Kow (Log Pow):

1.12

at the temperature of:

20 °C

Additional information

In Veith et al. (in: Aquatic Toxicology, ASTM STP 707, 1980, pp. 116 -129.), the results of a detailed study using a methodology similar to OECD Guideline No. 107 (shake-flask method) are reported. In the conditions of the test, the Log Pow of Bis(2-chloroethyl) ether was found to be equal to 1.12. The data originate from a peer-reviewed publication and is deemed reliable (reliability score of 2).

In a review on partition coeffcients and their uses published by Leo et al. (Chem. Rev., 1971, 71(6):525-616), experimental data on the partition coefficient of Bis(2-chloroethyl) ether are reported. The data was generated based on a shake-flask method, but no extra methodological details are provided. The Log Pow of Bis(2-chloroethyl) ether was determined to be 1.58.

In the databook entitled "Aquatic Fate Porcess Data for Organic Priority Pollutants" published by U.S. EPA (Mabey et al., 1982), a Kow value equal to 29 is reported for Bis(2-chloroethyl) ether. U.S. EPA reports are subjected to a formal review process. It is thus assumed that a variety of data sources have been consulted, that the test methodology and identity of the test substance has been evaluated, and that a reliable and representative value for the endpoint has been selected. Accordingly, this data was assigned a reliability score of 2.