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EC number: 203-870-1 | CAS number: 111-44-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Henry's Law constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- Henry's law constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test: Equilibrium Partitioning in Closed Systems (EPICS)
- Short description of test conditions: measurement of multiple pairs of high/low volume closed systems to obtain several independent estimates of Henry's law constant. - GLP compliance:
- not specified
- Specific details on test material used for the study:
- TEST MATERIAL
- Names (as cites): bis(2-chloroethyl)ether
- Purity: > 99% - H:
- 0.001 atm m³/mol
- Temp.:
- 10 °C
- H:
- 0 atm m³/mol
- Temp.:
- 15 °C
- Key result
- H:
- 0.001 atm m³/mol
- Temp.:
- 20 °C
- H:
- 0 atm m³/mol
- Temp.:
- 25 °C
- H:
- 0 atm m³/mol
- Temp.:
- 30 °C
- Conclusions:
- Henry's constant for Bis(2-chloroethyl) ether was determined to be 72.04E-05 atm m3/mol at 20°C.
- Executive summary:
In this well documented study from the Engineering & Services Laboratory of the Tyndall Air Force Base (U.S.A.), Henry's law constant of Bis(2-chloroethyl) ether was measured at various temperature (10-30°C) based Equilibrium Partitioning in Closed Systems (EPICS). Appropriate control procedure were in place to ensure data reliability. Henry's constant for Bis(2-chloroethyl) ether was determined to be 72.04E-05 atm m3/mol at 20°C.
The report has been subjected to a formal review process. Accordingly, it has been assigned a reliability score of 2.
Reference
TEMPERATURE REGRESSION EQUATION:
The data generated from this study were used to to generate temperature regression equations based on the theoretical constant-pressure temperature dependence of Henry's law constant. The "enthalpy of volatilization" is assumed constant over the entire temperature range in the regression, even though such a simplification may not always be physically realistic.
The temperature regression parameters and error bands (at 25°C) for Bis(2-chloroethyl) ether is provided below:
Temperature regression | 95% confidence interval | |||
Slope | Intercept | Fit (R2) | Lower (%) | Upper (%) |
1.5763E+04 | -6.2146E+01 | 0.6716 | -86.83 | 659.06 |
The fit of the linear regression was moderate. This may originate from a nonlinear Henry's law constant behavior or from high coefficient of variation (COV) of replicates measurement at a given temperature (see below).
HENRY'S LAW CONSTANT MEASUREMENTS:
High coefficient of variation (COV) of replicates measurement were observed for Bis(2 -chloroethyl) ether. However, this result is not suprising as Henry's Law constant values for the test substance are low and thus measurement variability (expressed in COV) is logically higher. Henry's constants at various temperature and associated COV are reported below:
Temperature | Henry's Constant (atm m3/mol) |
Coefficient of variation (%) |
10°C | 124.75E-05 | 75.96 |
15°C | 16.58E-05 | 347.46 |
20°C | 72.04E-05 | 28.41 |
25°C | 12.53E-05 | 92.84 |
30°C | 1.38E-05 | 697.60 |
Description of key information
In this well documented study from the Engineering & Services Laboratory of the Tyndall Air Force Base (U.S.A.), Henry's law constant of Bis(2-chloroethyl) ether was measured at various temperature (10-30°C) based Equilibrium Partitioning in Closed Systems (EPICS). Appropriate control procedure were in place to ensure data reliability. Henry's constant for Bis(2-chloroethyl) ether was determined to be 72.04E-05 atm m3/mol at 20°C.
The report has been subjected to a formal review process. Accordingly, it has been assigned a reliability score of 2.
Key value for chemical safety assessment
- Henry's law constant (H) (in Pa m³/mol):
- 72.99
- at the temperature of:
- 20 °C
Additional information
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