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EC number: 259-627-5 | CAS number: 55406-53-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-04-27 to 1984-07-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-iodo-2-propynyl butylcarbamate
- EC Number:
- 259-627-5
- EC Name:
- 3-iodo-2-propynyl butylcarbamate
- Cas Number:
- 55406-53-6
- Molecular formula:
- C8H12INO2
- IUPAC Name:
- 3-iodoprop-2-yn-1-yl butylcarbamate
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored at room temperature
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Kingston, New York
- Weight at study initiation: initial body weights did not exceed 20 % of mean body weights
- Fasting period before study: overnight
- Housing: individually in suspended wire-mesh cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: approx. one week
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: as appropriate
- Lot/batch no.: 52500
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- 250; 500; 1000; 1500; 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation at one, two, and four hours post treatment, and once daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology - Statistics:
- The mortality data were analyzed separately for males by a modified Behrens-Reed-Muench Cumulant Method (Thakur and Fezio, 1981). For the females and for the sexes combined. LD50´s and their 95 % confidence intervals were computed using a maximum likelihood Logit Method (Bliss, 1952).
Results and discussion
- Preliminary study:
- The Group 2 (1000 mg/kg bw) animal was found dead on Day 2 postdose; the Group 3 (1500 mg/kg bw) animal at 4 hours; the Group 4 (2000 mg/kg bw) animal on Day 3; and the Group 5 (2500 mg/kg bw) animal was found dead on Day 2. Clinical observations included rough coat in all groups; soft feces and urine stains in all treatment groups, except Group 3; slight depression and/or depression in Groups 2, 3, 4 and 5; and red stains on the nose and/or eyes and hunched appearance in Group 4. Animals in Groups 3, 4, and 5 lost weight between initiation and death. The Group 2 animal gained weight.
All surviving animals had no observable gross pathology findings at necropsy. In the animals which were found dead, gross pathology findings were noted for the lung, stomach, intestines, and liver.
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 795 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 437 - < 2 243
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 056 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 783 - < 1 329
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 470 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 226 - < 1 713
- Clinical signs:
- other: Clinical observations included soft feces, rough haircoat, urine stains, and slight depression and/or depression in all groups; ataxia, hunched appearance and prostration in Groups 3, 4 and 5; labored respiration in Group 3 and 4; and tremors in Group 5.
- Gross pathology:
- All surviving animals had no observable gross pathology findings at necropsy. In the animals which were found dead, gross pathology findings were noted for the stomach, intestine, kidneys, and liver.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 of the test item for acute oral toxicity is determined to be 1056 mg/kg bw for female Sprague Dawley rats.
- Executive summary:
The test item was evaluated for acute oral toxicity in male and female rats. Based upon the findings of this study, the acute oral LD50 in males was calculated to be 1795 mg/kg bw, with 95 % confidence limits of 1437 and 2243 mg/kg bw; the oral LD50 in females was calculated to be 1056 mg/kg bw, with 95 % confidence limits of 783 and 1329 mg/kg bw; and the combined LD50 in males and females was calculated to be 1470 mg/kg bw, with 95 % confidence limits of 1226 and 1713 mg/kg bw.
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