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EC number: 613-645-3 | CAS number: 646505-36-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Desmorapid 01 can be chemically described as ‘butanoic acid, 3-oxo-, methylester, reaction products with N,N-dimethyl-1,3-propanediamine and propylene glycol ether with trimethylol propane (3:1) (CAS-No. 646505-36-4)’ or (different description of the same substance) ‘poly [oxy(methyl-1,2-ethanediyl)] , a -hydro-w -hydroxy-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1), 3-[[3-dimethylamino) propyl]imino]butanoate’ (CAS-No. 857285-61-1). The closely related CAS-No. 179733-18-7 describes the same substance and differs only in the manufacturing process where ethanol is distilled off while for the other two CAS-Nos. methanol is distilled off (see IUCLID section 1.1). Thus, toxicological data for all three CAS-Nos. are considered relevant for the substance to be registered and are taken into account for human health assessment.
The test substance (CAS-No. 646505-36-4) was evaluated in an Ames Test on Salmonella typhimurium strains TA 1535, TA 100, TA, 1537, TA 98, and TA 102, performed according to OECD TG 471. The test material was considered to be non-mutagenic without and with S9 mix in the plate incorporation as well as in the preincubation modification of the Salmonella/microsome test.
The test substance (CAS-No. 646505-36-4) was investigated for a mutagenic potential in an in vitro gene mutation assay on V79 cells (HPRT) according to OECD TG 476 in concentrations of up to and including 180 µg/mL without S9 mix and 900 µg/ml with S9 mix. The highest concentrations induced acceptable levels of cytotoxicity. Cultures with higher concentrations were not continued due to exceedingly strong toxic effects. No relevant and reproducible increase of the mutation frequency was observed in the cultures with and without S9 mix. Based on these results the test substance is considered to be non-mutagenic in the V79/HPRT test.
The clastogenic and aneugenic potential of the test substance (CAS-No. 646505-36-4) was evaluated in an in vitro micronucleus test with Chinese hamster V79 cells according to OECD TG 487. Cytotoxic effects were assessed by relative increase in cell count (RICC) as well as the proliferation index (PI). The micronucleus test showed no increase in the frequencies of micronucleus containing V79 cells treated with the test item in the absence (4 hour or 24 hour treatment) or in the presence of S9 mix (4 hour treatment) up to cytotoxic concentrations. Therefore, the test item is considered to be non-clastogenic (no induction of structural chromsomal aberrations) and non-aneugenic (no induction of misdistribution of chromosomes) under the conditions of the in vitro micronucleus test.
Justification for selection of genetic toxicity endpoint
no study was selected, since all three in vitro studies were negative
Short description of key information:
Clearly negative in vitro studies - both with and without metabolic activation
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the negative results of several mutagenicity tests no classification is required with regard to genetic toxicity.
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