Registration Dossier
Registration Dossier
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EC number: 222-315-4 | CAS number: 3423-28-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- EC Number:
- 222-315-4
- EC Name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- Cas Number:
- 3423-28-7
- Molecular formula:
- C10H17NO
- IUPAC Name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 4h
- Observation period:
- 72h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Other effects:
- There were no significant body weight changes during the contact and observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Considering the reported data of this irritation study it can be stated that the test item N-Isopropylnortropinon showed no irritant/corrosive effects.
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