Registration Dossier
Registration Dossier
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EC number: 222-315-4 | CAS number: 3423-28-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- EC Number:
- 222-315-4
- EC Name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- Cas Number:
- 3423-28-7
- Molecular formula:
- C10H17NO
- IUPAC Name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- Test material form:
- other: liquid
Constituent 1
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In conclusion, it can be stated that during the described mutagenicity test and under the experimental conditions reported, the test item did not
cause gene mutations by base pair changes or frameshifts in the genome of the tester strains used.
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