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Diss Factsheets
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EC number: 939-340-8 | CAS number: 28182-81-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well-documented study that meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Mice were intraperitoneally administered a single dose of the test substance. The animals were observed for mortality and clinical signs of toxicity and necropsied at death or after the observation period of 14 days.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 28182-81-2
- Molecular formula:
- Unspecified (UVCB substance)
- Reference substance name:
- Reference substance 002
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ivanovas
- Weight at study initiation (mean): 20.3 g (males), 19.5 g (females)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: ethyl acetate
- Doses:
- 1474, 2150, 3160, 3830, 4640, 5620, 6810 and 10000 mg/kg bw (50% solution)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on day 0, daily in the following days
- Frequency of weighing: day 0, 3, 7 and 11-13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 850 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Corresponding to 1700 mg/kg bw of the applied 50% solution.
- Mortality:
- - 1474 mg/kg bw: 3/10
- 2150 mg/kg bw: 8/10
- 3160 mg/kg bw: 7/10
- 3830, 4640, 5620, 6810 and 10000 mg/kg bw: 10/10 - Clinical signs:
- dyspnoea, apathy, staggering, bad general state, lateral position in some animals, atonia, narcose-like state, tremor, exsiccose, spastic gait, lagrimation
- Gross pathology:
- substance residues and adhesions in stomach and abdomen
Any other information on results incl. tables
Table 1: Mortality and mean body weight
Dose (mg/kg bw) |
Sex |
Mean body weight (g) |
Mortality |
|||||||
Day 0 |
Day 3 |
Day 7 |
Day 11-13 |
1 h |
24 h |
48 h |
7 d |
14 d |
||
10000 |
M |
21 |
- |
- |
- |
5 |
5 |
5 |
5 |
5 |
F |
18 |
- |
- |
- |
5 |
5 |
5 |
5 |
5 |
|
6810 |
M |
19 |
- |
- |
- |
4 |
5 |
5 |
5 |
5 |
F |
20 |
- |
- |
- |
5 |
5 |
5 |
5 |
5 |
|
5620 |
M |
18 |
- |
- |
- |
3 |
4 |
4 |
5 |
5 |
F |
18 |
17 |
- |
- |
4 |
4 |
4 |
5 |
5 |
|
4640 |
M |
18 |
16 |
- |
- |
2 |
4 |
4 |
5 |
5 |
F |
19 |
17 |
- |
- |
3 |
4 |
4 |
5 |
5 |
|
3830 |
M |
18 |
- |
- |
- |
0 |
4 |
4 |
5 |
5 |
F |
19 |
17 |
- |
- |
1 |
3 |
4 |
5 |
5 |
|
3160 |
M |
17 |
17 |
20 |
20 |
0 |
0 |
0 |
3 |
3 |
F |
19 |
20 |
25 |
26 |
1 |
2 |
3 |
4 |
4 |
|
2150 |
M |
26 |
21 |
- |
- |
0 |
0 |
1 |
5 |
5 |
F |
20 |
20 |
21 |
21 |
0 |
1 |
2 |
3 |
3 |
|
1474 |
M |
26 |
25 |
30 |
31 |
0 |
1 |
1 |
3 |
3 |
F |
20 |
22 |
24 |
25 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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