Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-340-8 | CAS number: 28182-81-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Skin: slightly irritating, not indicative for classification.
Transient signs of mild skin irritation were observed in the Key study (BASF SE, 1992) and in 2 of the 3 supporting studies. All studies were performed according to or similar to the OECD test guideline 404.
Eye: not irritating
In an OECD TG405 study no signs of eye irritation were described (Rhone-Poulenc, 1983)
Respiratory tract: irritating to the respiratory tract
Signs of lower respiratory tract irritation observed in all acute and repeated dose inhalation toxicity studies.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
The Key study was performed according to the OECD test guideline 404. 0.5ml of the undiluted test substance was applied to the intact skin of 3 rabbits under semiocclusive conditions for 4 h. Slight erythema (scores: 0.33, 1.67 and 1.33) was observed, but was fully reversible within 48 h, 8 d and 72 h, respectively. Edema (scores: 0, 0.33 and 0.33) was reversible within 48 h (BASF AG, 1992).
3 additional studies of acceptable reliability are available to substantiate the test result:
In a guideline-conform study (OECD TG 404), the undiluted test substance was applied to the intact skin of 3 male rabbits (0.5ml, 4h, semiocclusive). No edema or erythema was reported on any animal (Rhone Poulenc Inc. 1983).
A study performed according to OECD TG 404, the undiluted test substance was applied to the intact skin of 6 male rabbits (0.5ml, 4h, semiocclusive). Mild erythma was observed in all animals (grade 1,2), edema (gade 1) was observed in 5 of 6 animals.Though a limited observation period of only 72h has to mentioned as a significant shortcoming of this study, a clear tendency for a full reversibility can be postulated from the raw data (Hazelton, 1986).
Finally a further guideline-conform study (OECD TG 404) is reported (Bushy RRC, 1991). 0.5ml of the undiluted test substance were applied for 4h to the clipped skin of 3 male and 3 female animals under occlusive conditions. Reversible erythema (grade 1 and 2) and edema in one animal were identified as indicators of slight skin irritation.
Eye irritation
They study for eye irritation was performed in 3 male rabbits according to the OECD test guideline 405. In brief, 0.1ml of the undiluted test substance were applied to the conjunctival sac of each animal. The treated eyes were not rinsed.
1 and 24h following application all 3 animals displayed mild conjunctival reness (grade1) which was reversible in all animals after 72h. No other signs of eye irritation were described (Rhone-Poulenc, 1983).
Respiratory Tract irritation:
HDI Trimer (biuret) has shown to be a respiratory tract irritant in a variety of acute inhalation bioassays.
For details please consult End Point Summary of chapter Acute Toxicity.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Dangerous substance Directive (67/548/EEC)
The available experimental test data are considered reliable and suitable for the purpose of classification. Based on the criteria of Directive 67/548/EEC, as amended for the 28thtime in Directive 2001/59/EC, classification for skin and eye irritation is not warranted.
Though the substance has to be classified as an respiratory tract irritant (Xi, R37).
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification. Based on the criteria laid down in Regulation (EC) No. 1272/2008, as amended for the 2ndtime in Directive EC 286/2011, classification for skin and eye irritation is not warranted.
Though the substance has to be classified as an respiratory tract irritant (STOT Single Exp. 3, H335: May cause respiratory irritation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)