Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-505-5 | CAS number: 16455-61-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
Hydrolysis of EDDHA-moiety containing chelates was studied by means of determination of their stability constants and species distribution in solution, hydroponic and soil condition. The tendency to hydrolysis of EDDHA chelates is a function of the stability, i.e. the more stable the complex, the less prone it is to hydrolyze (Ahrland et al., 1990). The recovery of 100 % was observed for EDDHA/Fe3+ at pH 12.76. The value of pKa(FeL-) (not hydrolysed species) was about 2 units higher than the actual value of pH tested. The author concluded that EDDHA/Fe3+ did not hydrolyse even in the most alkaline soils (pH >9).
A high Fe3+ ion affinity was observed for o,o- and o,p-EDDHA (Yunta et al., 2003a,b). In the studies on determination of stability constants by spectrophotometric and potentiometric measurements, the predominant species of o,o-EDDHA/Fe3+ involved the coordination with the nitrogen atoms, the carboxylate oxygens, and the phenolate groups (FeL- species). The protonated (FeHL) and hydroxylated (FeOHL2-) species were predominant at pH below 3 and above 10, respectively (Yunta et al., 2003b). Both isomers of EDDHA chelate formed stable complexes over the environmental pH range. The stability constants of the hydroxylated species FeOHL2- were significantly lower than the stability constants of the protonated species in both isomers (Yunta et al., 2003a,b). The hydroxylated species FeLOH2- of o,p-EDDHA/Fe3+ was formed also only at pH 9.27 (Yunta et al., 2003a).
According to species distribution studies in nutrient solution, the not hydrolysed FeL species of o,o-EDDHA/Fe3+ was predominant in the whole physiological pH range (Yunta et al., 2003b). 100% of the iron chelate remained as FeL- species at pH below 11. The hydroxylated FeOHL2- species appeared at pH around 11.5. Only at pH above 11.5 became the calcium and magnesium chelates predominant species (iron was displaced from the chelate) (Yunta et al., 2003b). Similarly to o,o-EDDHA/Fe3+, the protonated species of o,p-EDDHAHx/Fe3+ were the predominant species at agronomic pH in the studies on species distribution at agronomic conditions in three theoretical models. Hydroxylated species were formed at pH 10 and 11.5 in solution and nutrient solution models, respectively. According to authors, in soils with limited Cu availability, FeLOH2- of o,p-EDDHA/Fe3+ could also be formed at pH > 11 (Yunta et al., 2003a).
Based on these results, it can be concluded that the target substance o,o-Fe(Na)EDDHA is hydrolytically stable at environmental pH range.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.