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Diss Factsheets
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EC number: 294-436-0 | CAS number: 91722-33-7 A complex combination of organic compounds separated after condensation of the vapors from the destructive distillation of wood.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Remarks:
- pre-natal toxicity (OECD 414)
- Type of information:
- experimental study planned
- Justification for type of information:
- TESTING PROPOSAL ON VERTEBRATE ANIMALS - OECD 414
NON-CONFIDENTIAL NAME OF SUBSTANCE:
tar, wood
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies: Available GLP studies are available in the registration dossier, including a 90-day repeat dose toxicity study. However, none of the available GLP studies fulfil the requirements of the Prenatal Developmental Toxicity Study. No GLP studies on developmental toxicity on the substance itself were identified in literature search.
- Available non-GLP studies: No non-GLP studies on developmental toxicity on the substance itself were identified in literature search.
- Historical human/control data: There are no appropriate historical human data available addressing the developmental toxicity endpoint.
- (Q)SAR: There are no reliable QSAR models addressing the endpoint of developmental toxicity to the extent that is assessed in a Prenatal Developmental Toxicity Study.
- In vitro methods: No validated or regulatory accepted alternative methods are available for replacing animal testing with respect to developmental toxicity.
- Weight of evidence: Considering the lack of valid, regulatory accepted in vitro methods, QSAR models and test data a weight of evidence approach is not possible.
- Grouping and read-across: Tar, wood is a complex UVCB. Read-across using developmental toxicity data on certain constituents of the UVCB was investigated but it was considered that there were no predominant constituents in the UVCB composition to justify a read-across to a single or group of the constituents, also taking into consideration the potential differences individual constituents in physico-chemical properties and possible mechanisms of action.
- Substance-tailored exposure driven testing: An exposure based waiving is not appropriate based on the uses of substance (including consumer uses) and exposure scenarios generated.
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
The column 2 adaptations for pre-natal developmental toxicity (Annex IX, 8.7) are not appropriate based on the following:
-the substance is known to be genotoxic carcinogen and appropriate risk management measure are implemented: The substance is not a known genotoxic carcinogen.
-the study does not need to be conducted because the substance is known to be a germ cell mutagen and appropriate risk management measures are implemented: The substance is not a known germ cell mutagen.
-study does not need to be conducted because substance is of low toxicological activity (no evidence of toxicity in any test), it can be proven from toxicokinetic data that no systemic absorption occurs via relevant routes of exposure (e.g. plasma/blood concentrations below detection limit using a sensitive method and absence of the substance and of metabolites of the substance in urine, bile or exhaled air) and there is no or no significant human exposure: The conditions of this waiver are not met based on available data and uses (for the human exposure criteria).
-no testing necessary because the substance is known to cause developmental toxicity: Substance not known to cause developmental toxicity, but OECD 414 proposed.
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
An OECD 414 is proposed to address the REACH endpoint requirements for developmental toxicity (which is currently not covered by available data in the registration). In addition an OECD 414 study will also be able to include end points to evaluate any endocrine disruption effects, such as thyroid hormone analysis, which the existing 90-day study does not cover. A proposal for a OECD 414 study will address effects on the developing fetus and it is considered that as a definitive study this will provide sufficient information without the need for screening study (OECD 421).
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Version / remarks:
- 2018
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tar, wood
- EC Number:
- 294-436-0
- EC Name:
- Tar, wood
- Cas Number:
- 91722-33-7
- Molecular formula:
- not applicable
- IUPAC Name:
- Tar, wood
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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