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EC number: 284-325-5 | CAS number: 84852-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The selected key study, Watanabe et al (2017) exposed Japanese medaka,Oryzias latipes, to nonylphenol for 16 weeks in a flow-through system. The key value is a NOEC for fertilised eggs, F0 and F1 generations of 0.000127 mg/l or 1.27µg/L.
For the marine environment, the only species with chronic toxicity data is the Flounder, Pleuronectes americanus. This result is based on the acute to chronic ratio (ACR) calculated from the acute test result by Lussier et al (2000) using the most conservative ACR determined for the fish species Onchorynchus mykiss. This method determined a NOEC value of 0.00046mg/l.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 0 mg/L
Additional information
The study by Watanabe et al (2017) was selected as the key study because of the high level of documentation and this study provided the lowest NOEC value for standard test endpoints such as growth, reproduction and survival that indicated Oryzias latipes was more sensitive than other standard test species, such as Pimephales promelas.
Several studies including nine different species of freshwater fish exposed to nonylphenol were found to be reliable (Klimisch 1 or 2). The studies included tests with preferred test species O. latipes, P. promelas, Danio rerio and Oncorhynchus mykiss, but reliable studies with marine fish species were not found. Test duration ranged from 21 to 365 days with NOEC endpoints reported for survival, growth, and reproduction (also expressed as fecundity or fertility). The range of NOEC values for survival were comparable and ranged from >0.0019 mg nonylphenol/L for O. latipesto 0.0775 mg nonylphenol/L for P. promelas (Brook 1993) compared to a NOEC range for growth from 0.006 mg nonylphenol/L for O. mykiss (Brooke 1993) to 0.038 mg nonylphenol/L for Pimephales promelas (Brooke 1993b), and a NOEC range for fertility of 0.0082 to 0.051 mg nonylphenol/L reported by Yokota et al (2001) and Kang et al (2003), respectively, for O. latipes. Based on the data available, inhibition of growth and reduction in reproduction (fertility) appeared to be an equally sensitive response to exposure of nonylphenol to fish. Of the species tested, the preferred species O. mykissand and O. latipes, appeared to be equally sensitive to nonylphenol exposure for the growth endpoints and more sensitive than P. promelas for the same endpoint.
The chronic toxicity of nonylphenol to Flounder, Pleuronectes americanus, was also assessed by application of the acute to chronic ratio (ACR). The most conservative ACR determined based on acute and chronic data for the Onchorynchus mykiss was applied to the Flounder acute study data from the Lussier et al study (2002). The NOEC was calculated at 0.0005mg/l. This is the only study that relates to marine species.
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