Registration Dossier
Registration Dossier
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EC number: 255-255-2 | CAS number: 41198-08-7
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption
- Remarks:
- adsorption/desorption
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- other: 163.1: Soil Adsorption/Desorption
- GLP compliance:
- yes
- Type of method:
- batch equilibrium method
- Media:
- soil
- Radiolabelling:
- yes
- Test temperature:
- 25 +/-1 degrees C
- Details on matrix:
- Soil characterised as a Sandy Loam.
- Details on test conditions:
- 25 +/- 1 degree C
- Type:
- Koc
- Value:
- 995.12
- Temp.:
- 25 °C
- % Org. carbon:
- 1.57
- Type:
- Kd
- Value:
- 13.786
- Temp.:
- 25 °C
- % Org. carbon:
- 1.57
- Type:
- other: 1/N
- Value:
- 0.87
- Temp.:
- 25 °C
- % Org. carbon:
- 1.57
- Adsorption and desorption constants:
- Adsorption Kd = 13.7862, desorption Kd= 13.7862
- Recovery of test material:
- An average of 93% was recovered (89.92 to 99.79 %)
- Concentration of test substance at end of adsorption equilibration period:
- 6.4498, 6.2831, 2.9050, 2.9862, 0.5212, 0.5217, 0.2457, 0.2570, 0.0954, 0.0924
- Concentration of test substance at end of desorption equilibration period:
- 2.7168, 2.0458, 1.0571, 1.0234, 0.2273, 0.2273, 0.1098, 0.1131, 0.0457, 0.0460
- Sample no.:
- #1
- Duration:
- 24 h
- % Adsorption:
- >= 43.6 - <= 64.2
- Sample no.:
- #1
- Duration:
- 24 h
- % Desorption:
- >= 20.1 - <= 22.3
- Transformation products:
- yes
- No.:
- #1
- Statistics:
- Correlation coefficient > 0.99
- Conclusions:
- A GLP study following an EPA guideline. One soil only with a Koc of 995. One metabolite formed CGA 55960 formed at 6.5%.
- Executive summary:
An adsorption-desorption GLP study on one soil at 5 test concentrations. Mean recovery was 93%. Koc was 995 which indicates that profenofos is slightly mobile in soil (McCall classification).
- Endpoint:
- adsorption / desorption
- Remarks:
- adsorption
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 10 to 50g of oven dried soil was mixed with 100ml of aqueous solutions of 1.0 to 10.0 ppm of profenofos and shaken on a mechanical shaker in water bath at 25 +/- 1 degree C for a minimum of 24 hours. The liquid was separated by centrifugation and 0.5 ml aliquots of the supernatant were mixed with scintillation solution and quantified.
- GLP compliance:
- no
- Type of method:
- other: Laboratories own
- Media:
- soil
- Radiolabelling:
- yes
- Test temperature:
- 25 +/- 1 degree C
- Analytical monitoring:
- not specified
- Details on matrix:
- 4 soils (3 Swiss and 1 US) with pHs between 6.1 and 7.8 and organic matter between 1.2% and 5.6%.
- Computational methods:
- Equilibrium concentration calculated by means of a calibration equation. Results were assessed with the aid of the empirical Freundlich adsorption isotherm.
- Type:
- Kd
- Remarks:
- ug adsorbed per g of soil
- Value:
- 4.56
- Temp.:
- 25 °C
- % Org. carbon:
- 1.28
- Remarks on result:
- other: calculated
- Type:
- Kd
- Remarks:
- ug adsorbed per g of soil
- Value:
- 20.2
- Temp.:
- 25 °C
- % Org. carbon:
- 0.7
- Remarks on result:
- other: calculated
- Type:
- Kd
- Remarks:
- ug adsorbed per g of soil
- Value:
- 22.2
- Temp.:
- 25 °C
- % Org. carbon:
- 2.09
- Remarks on result:
- other: calculated
- Type:
- Kd
- Remarks:
- ug adsorbed per g of soil
- Value:
- 55.6
- Temp.:
- 25 °C
- % Org. carbon:
- 3.25
- Remarks on result:
- other: calculated
- Phase system:
- other: 1/n
- Type:
- other: 1/n
- Value:
- 0.94
- Phase system:
- other: 1/n
- Type:
- other: 1/n
- Value:
- 0.7
- Phase system:
- other: 1/n
- Type:
- other: 1/n
- Value:
- 0.89
- Phase system:
- other: 1/n
- Type:
- other: 1/n
- Value:
- 0.78
- Transformation products:
- not specified
- Conclusions:
- Though this study was not carried out to modern guidelines the method is well documented and a range of soils were used.
- Executive summary:
A study of the adsorption of profenofos onto 4 soils was carried out at ca 25 degrees C. Results indicate that profenofos would have low mobility in soil (McCall classification) with a mean Koc being calculated of 1504.
Referenceopen allclose all
Description of key information
Mean Koc of 1402 indicating that profenofos has low mobility in soil.
Key value for chemical safety assessment
- Koc at 20 °C:
- 1 402
Additional information
Two studies covering 5 soils with Koc's ranging from 356 to 2886 with a mean of 1402. Using the McCall classification profenofos has low mobility in soil.
These studies were carried out at 25 degrees C.
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