Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No guideline, not GLP.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1958
Report date:
1958

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The acute intraperitoneal toxicity of the test substance was determined in albino rats exposed to three different environmental temperatures: 8℃, 26℃ and 36℃.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
nonasodium 2-({6-[(2-carboxylato-4-hydroxy-6-{[6-hydroxy-5-(sulfonatoamino)-4-(sulfonatooxy)-2-[(sulfonatooxy)methyl]oxan-3-yl]oxy}-5-(sulfonatooxy)oxan-3-yl)oxy]-4-hydroxy-5-(sulfonatoamino)-2-[(sulfonatooxy)methyl]oxan-3-yl}oxy)-4-hydroxy-3-(sulfonatooxy)-3,4-dihydro-2H-pyran-6-carboxylate
EC Number:
700-834-1
Cas Number:
9041-08-1
Molecular formula:
not applicable (UVCB substance)
IUPAC Name:
nonasodium 2-({6-[(2-carboxylato-4-hydroxy-6-{[6-hydroxy-5-(sulfonatoamino)-4-(sulfonatooxy)-2-[(sulfonatooxy)methyl]oxan-3-yl]oxy}-5-(sulfonatooxy)oxan-3-yl)oxy]-4-hydroxy-5-(sulfonatoamino)-2-[(sulfonatooxy)methyl]oxan-3-yl}oxy)-4-hydroxy-3-(sulfonatooxy)-3,4-dihydro-2H-pyran-6-carboxylate
Details on test material:
Batch No.: not specified
Purity: not specified

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200-250 g
- Acclimation period: The animals were placed in the respective rooms 40-45 minutes before treatment.

ENVIRONMENTAL CONDITIONS
- Temperature (°C): Each rat of one group was treated in the cold room maintained at 8±1℃. The second group was injected at room temperature, 26±1℃, while the third group was kept in a hot room where the temperature was maintained at 36±1℃.
- Humidity (%): At 36℃ the relative humidity was 35±2%, at 26℃ it was 55±4%, and at 8℃ it was 90±2%.

No additional data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
None stated
Doses:
None stated
No. of animals per sex per dose:
None stated
Control animals:
not specified
Details on study design:
None stated
Statistics:
None stated

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
180 mg/kg bw
Based on:
test mat.
Remarks on result:
other: At 8℃
Sex:
male/female
Dose descriptor:
LD50
Effect level:
420 mg/kg bw
Based on:
test mat.
Remarks on result:
other: At 26℃
Sex:
male/female
Dose descriptor:
LD50
Effect level:
120 mg/kg bw
Based on:
test mat.
Remarks on result:
other: At 36℃
Mortality:
No information provided
Clinical signs:
No information provided
Body weight:
No information provided
Gross pathology:
No information provided
Other findings:
No information provided

Applicant's summary and conclusion

Conclusions:
The test substance was most toxic at 36℃.