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EC number: 202-818-5 | CAS number: 100-09-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2), and is thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, of Regulation (EC) No 1907/2006.
- Endpoint conclusion:
- no study available
- Endpoint conclusion:
- no study available
Oral (equivalent or similar to OECD 401), rat: LD50 > 5000 mg/kg bw
A reliable study regarding acute oral toxicity is available for the test substance. The acute oral toxicity of the test substance was assessed in a study performed equivalent or similar to OECD Guideline 401 (Bayer, 1979). Two groups of 10 male Wistar rats were treated with the test material at dose levels of 3100 and 5000 mg/kg bw. The test material was administered by gavage using peanut oil as vehicle. The animals were observed for 14 days. At the high dose two animals died on day 4 and all animals showed clinical signs of toxicity (diarhoea and increased diuresis). Neither mortalities nor clinical signs were noted at 3100 mg/kg bw.
The acute oral LD50 value of the test material was therefore > 5000 mg/kg bw.
The available data on acute toxicity of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 and are therefore conclusive but not sufficient for classification.
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - The test was conducted before guideline was adopted.
- Principle of test: the test substance was applied to one auricle (inner surface) of each of 2 rabbits under semi-occlusive conditions for 24 hours. After the exposition remaining test item was removed by washing. Observations were made at removal of test item, after 24, 48 and 72 h as well as 7 days after application
- Parameters analysed / observed: erythema, edema and eschar formation - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3-4 kg
- Housing: single housing
- Diet: typal feeding, ad libitum
- Water: ad libitum - Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- ; the test item was moistened with water before application
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 500 mg - Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 days
Reading time points: after washing, 24, 48 and 72 h and 7 days - Number of animals:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: with water and soap
- Time after start of exposure: 24 h
OBSERVATION TIME POINTS
- after washing, 24, 48 and 72 h and 7 days
SCORING SYSTEM:
- the scoring system used for interpretation of the skin reaction was not specified - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- other: eschar formation
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- At none of the reading time points, reactions indicative of skin irritation were noticed.
- Other effects:
- - Adverse systemic effects: no systemic effects were reported.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a reliable study, that was conducted prior to implementation of the current guidelines, the skin irritation potential of p-anisic acid was tested by semiocclusive application of the test substance to rabbit ears for 24 h. No skin reaction was noted at any reading time point thus under the conditions of the test the compound was not a skin irritant.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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