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EC number: 202-818-5 | CAS number: 100-09-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - The test was conducted before guideline was adopted
- Principle of test: the test substance was applied to the left conjunctical sacs of two rabbits, observations were made 1, 24, 48, 72, 96 h as well as 7 days after application
- Parameters analysed / observed: conjunctival chemosis, reddening and swelling, corneal opacity, iritis - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3-4 kg
- Housing: single housing
- Diet: typal feeding, ad libitum
- Water: ad libitum - Vehicle:
- unchanged (no vehicle)
- Remarks:
- ; the test item was moistened with water before application
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 50 mg - Duration of treatment / exposure:
- not applicable as it is not specified whether the treated eyes were rinsed or not
- Observation period (in vivo):
- 7 days
Reading time points: 1, 24, 48, 72 and 96 h and 7 days - Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: not stated
SCORING SYSTEM:
- scoring was done but the scoring system used for interpretation of the eye reaction was not specified - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- A grade 1 conjunctivae redness was noted 1 h after instillation in both animals. At the 24 h reading time point, the conjunctivae redness graded 1 was still present in one animal, whereas in the second, the finding seems to become weaker, as based on the grading reported as (1). After 48 hours, no more conjunctivae redness was seen for both animals, indicating complete reversibility. No further effects were noticed.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a reliable study, that was conducted prior to implementation of the current guidelines, the eye irritation potential of p-anisic acid was tested in two rabbits. Eye reactions were restricted to conjunctivae redness which disappeared within 48 h. It was concluded that under the test conditions used, p-anisic acid was slightly and transiently irritant to the eye, but the obtained results do not warrant any classification as irritant to the eye.
Table 1: In Vivo Eye Irritation Scores
Animal No. |
Irritation parameter |
Reading times |
|||||
|
|
1h |
24 h |
48 h |
72 h |
96 h |
7 days |
21 |
cornea |
0 |
0 |
0 |
0 |
0 |
0 |
|
iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
conjunctiva |
1 |
1 |
0 |
0 |
0 |
0 |
|
chemosis |
0 |
0 |
0 |
0 |
0 |
0 |
|
lacrimation |
0 |
0 |
0 |
0 |
0 |
0 |
22 |
cornea |
0 |
0 |
0 |
0 |
0 |
0 |
|
iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
conjunctiva |
1 |
(1) |
0 |
0 |
0 |
0 |
|
chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
|
lacrimation |
0 |
0 |
0 |
0 |
0 |
0 |
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - The test was conducted before guideline was adopted.
- Principle of test: the test substance was applied to one auricle (inner surface) of each of 2 rabbits under semi-occlusive conditions for 24 hours. After the exposition remaining test item was removed by washing. Observations were made at removal of test item, after 24, 48 and 72 h as well as 7 days after application
- Parameters analysed / observed: erythema, edema and eschar formation - GLP compliance:
- no
Test material
- Reference substance name:
- p-anisic acid
- EC Number:
- 202-818-5
- EC Name:
- p-anisic acid
- Cas Number:
- 100-09-4
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 4-methoxybenzoic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3-4 kg
- Housing: single housing
- Diet: typal feeding, ad libitum
- Water: ad libitum
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- ; the test item was moistened with water before application
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 500 mg - Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 days
Reading time points: after washing, 24, 48 and 72 h and 7 days - Number of animals:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: with water and soap
- Time after start of exposure: 24 h
OBSERVATION TIME POINTS
- after washing, 24, 48 and 72 h and 7 days
SCORING SYSTEM:
- the scoring system used for interpretation of the skin reaction was not specified
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- other: eschar formation
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- At none of the reading time points, reactions indicative of skin irritation were noticed.
- Other effects:
- - Adverse systemic effects: no systemic effects were reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a reliable study, that was conducted prior to implementation of the current guidelines, the skin irritation potential of p-anisic acid was tested by semiocclusive application of the test substance to rabbit ears for 24 h. No skin reaction was noted at any reading time point thus under the conditions of the test the compound was not a skin irritant.
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