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EC number: 202-491-9 | CAS number: 96-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity testing was waived based upon the skin corrosive classification of the substance, however the European Commison has previous reviewed existing data on the substance and assigned the following harmonised classification and labelling: Toxic if swallowed (H301) and Harmful in contact with the skin (H312).
The following reliable oral toxicity values are presented in the literature: Mouse LD50 100mg/kg bw (Lewis, RL, 2005); rat LD50 110 mg/kg bw (Lewis RL, 2005) and rat LD50 140 mg/kg bw (Smyth et al, 1962), confirming the harmonised classification for oral toxicity.
A single reliable dermal toxicity value is available in the literature, an LD50 of 800 mg/kg bw in rabbits (Smyth et al, 1962), which supports the harmonised classification for dermal toxicity.
A harmonised classification for inhalation toxicity has not been assigned, however based upon the weight of evidence of human occupational toxicity (Shiozaki et al, 1994) and a reliable inhalation toxicity value in mice of 0.66 mg/L (Smyth et al 1962) a classification of Fatal if inhaled (H330) can reasonably be assigned.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- peer reviewed data published in handbook
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 100 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- Category 3 based on GHS criteria
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- peer reviewed data in a collection/handbook
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 110 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- Category 3 based on GHS criteria
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- peer reviewed data in a collection/handbook
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 140 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- Category 3 based on GHS criteria
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 100 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: report of occupational exposure
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Report of result of occupational exposure to the substance
- GLP compliance:
- no
- Remarks:
- Occupational exposure
- Test type:
- other: Occupational exposure
- Limit test:
- no
- Species:
- other: human
- Sex:
- male
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Sex:
- male
- Dose descriptor:
- other: mortality following occupational exposure
- Remarks on result:
- other: mortality following occupational exposure
- Mortality:
- Two of the five died from hepatic failure four and 11 days after the job
- Gross pathology:
- Autopsy showed
submassive hepatocellular necrosis in one of the individuals - Other findings:
- In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the
cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed. - Interpretation of results:
- other: mortality following occupational expoaure
- Conclusions:
- In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the
cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed.
Two of the five died from hepatic failure four and 11 days after the job. Autopsy showed
submassive hepatocellular necrosis in one of the individuals. The substance is toxic by inhalation and/or dermal exposure. - Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Peer reviewed data published in a collection of data
- GLP compliance:
- no
- Remarks:
- colleciton of data
- Test type:
- traditional method
- Limit test:
- no
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- ca. 4 h
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.66 mg/L air
- Based on:
- not specified
- Exp. duration:
- 4 h
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- Based on the LC50 of 0.66 mg/L/4 hours exposure the substance is classified as Acute toxicity (inhalation) Category 2.
Referenceopen allclose all
In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the
cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed.
Two of the five died from hepatic failure four and 11 days after the job. Autopsy showed
submassive hepatocellular necrosis in one of the individuals (e.g., total bilirubin levels were
significantly increased). At ~48 hours after exposure, the 1,3-DCP plasma level was 200 ng/mL.
Potential exposure to other chemicals was not reported
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 660 mg/m³
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study was reported in a collection of published data
- GLP compliance:
- no
- Remarks:
- collection of data published
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 800 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The results of the study indicate that classification as Acute toxicity Category 3 may be justified- the European Commission has assigned a harmonised classification of Acute toxicity (dermal) category 4
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 800 mg/kg bw
Additional information
Justification for classification or non-classification
Acute toxicity testing was waived based upon the skin corrosive classification of the substance, however the European Commison has previous reviewed existing data on the substance and assigned the following harmonised classification and labelling: Toxic if swallowed (H301) and Harmful in contact with the skin (H312).
The following reliable oral toxicity values are presented in the literature: Mouse LD50 100mg/kg bw (Lewis, RL, 2005); rat LD50 110 mg/kg bw (Lewis RL, 2005) and rat LD50 140 mg/kg bw (Smyth et al, 1962), confirming the harmonised classification for oral toxicity.
A single reliable dermal toxicity value is available in the literature, an LD50 of 800 mg/kg bw in rabbits (Smyth et al, 1962), which supports the
harmonised classification for dermal toxicity.
A harmonised classification for inhalation toxicity has not been assigned, however based upon the weight of evidence of human occupational toxicity (Shiozaki et al, 1994) and a reliable inhalation toxicity value in mice of 0.66 mg/L (Smyth et al 1962) a classification of Fatal if inhaled (H330) can reasonably be assigned.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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