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EC number: 283-291-9 | CAS number: 84604-14-8 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Rosmarinus officinalis, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1989
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, but considered sufficiently reliable for the purpose of hazard assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
- Type of study / information:
- Skin irritation potential of Rosemary oil was studied in healthy volunteers.
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Skin irritation potential of Rosemary oil was studied in healthy volunteers using epicutaneous and photo patch tests (UVA and UVB) and dermal reactions were observed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Rosemary, ext.
- EC Number:
- 283-291-9
- EC Name:
- Rosemary, ext.
- Cas Number:
- 84604-14-8
- Molecular formula:
- Not applicable for UVCB substance
- IUPAC Name:
- Essential oil of Rosmarinus officinalis L. (Lamiaceae) obtained from leaves, flowers and twigs by steam distillation
- Test material form:
- liquid
1
Method
- Details on study design:
- Skin irritation potential of undiluted Rosemary oil (Rosemary Ab. and Rosemary CO2 super critical in 25 and 20 healthy volunteers, respectively) was studied using epicutaneous test and photo patch tests (UVA and UVB) and dermal reactions were observed.
- Exposure assessment:
- measured
Results and discussion
- Results:
- - Rosemary Ab.: 23/25 subjects showed negative results and 2/25 subjects showed positive results. No phototoxic reactions were observed.
- Rosemary CO2 super critical: 19/20 subjects showed negative results and 1/20 subjects showed positive results. No phototoxic reactions were observed.
Any other information on results incl. tables
Table 7.10.5/1: Irritation and phototoxic effects on healthy volunteers
Product |
No. of patients tested |
Epicutaneous test |
Photopatch tests UVA |
Photopatch tests UVB |
Results |
||||||
Negative |
Positive |
Mean no. of crosses |
Identical to epicutaneous test |
Increased reaction |
phototoxic |
Identical to epicutaneous test |
Increased reaction |
phototoxic |
|||
Rosemary Ab. |
25 |
23 |
2 |
0.08 |
0.04 |
0 |
0 |
0.04 |
0 |
0 |
Weak irritant |
Rosemary CO2 super critical |
20 |
19 |
1 |
0.05 |
0 |
0 |
0 |
0.05 |
0 |
0 |
Weak irritant |
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, Rosemary oil is considered to be a weak irritant to skin in healthy volunteers.
- Executive summary:
In a study, undiluted Rosemary oil (Rosemary Ab. and Rosemary CO2 super critical in 25 and 20 healthy volunteers, respectively) was studied using epicutaneous and photo patch tests (UVA and UVB) and dermal reactions were observed.
- Rosemary Ab treated groups: 23/25 subjects showed negative results and 2/25 subjects showed positive results. No phototoxic reactions were observed.
- Rosemary CO2 super critical treated groups: 19/20 subjects showed negative results and 1/20 subjects showed positive results. No phototoxic reactions were observed.
Under the test conditions, Rosemary oil is considered to be a weak irritant to skin in healthy volunteers
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