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EC number: 203-207-6 | CAS number: 104-49-4
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26.06.2018 - 06.02.2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Identification: Paraphenylene diisocyanate (PPDI)
Appearance: White Chips
Batch: 20171126004
Purity/Composition: See Certificate of Analysis
Test item storage: At room temperature
Stable under storage conditions until: 21 December 2019 (expiry date)
Additional information
Test Facility test item number: 209403/A
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Irritant or corrosive: Yes
CAS number: 104-49-4 - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Temp.:
- 40 °C
- Remarks:
- The test item reacts immediately and completely with water when it comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be determined by following the reaction products either.
- Number of replicates:
- 6
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- An analytical method to determine the concentration of the intact test item in the test samples
could not be developed. The test item reacts immediately and completely with water when it
comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be
determined by following the reaction products either. - Transformation products:
- not measured
- Remarks:
- The test item reacts immediately and completely with water when it comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be determined by following the reaction products either.
- Details on hydrolysis and appearance of transformation product(s):
- An analytical method to determine the concentration of the intact test item in the test samples
could not be developed. The test item reacts immediately and completely with water when it
comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be
determined by following the reaction products either. - Key result
- pH:
- 7.7
- Temp.:
- 40 °C
- Type:
- not specified
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- The test item reacts immediately and completely with water when it comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be determined by following the reaction products either.
- Details on results:
- An analytical method to determine the concentration of the intact test item in the test samples
could not be developed. The test item reacts immediately and completely with water when it
comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be
determined by following the reaction products either. - Validity criteria fulfilled:
- not applicable
- Conclusions:
- An analytical method to determine the concentration of the intact test item in the test samples
could not be developed. The test item reacts immediately and completely with water when it
comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be
determined by following the reaction products either. - Executive summary:
An analytical method to determine the concentration of the intact test item in the test samples
could not be developed. The test item reacts immediately and completely with water when it
comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be
determined by following the reaction products either.
Reference
Description of key information
An analytical method to determine the concentration of the intact test item in the test samples could not be developed. The test item reacts immediately and completely with water when it comes into contact with aqueous matrices. Therefore, the hydrolysis rate could not be determined by following the reaction products either. A full supporting study is appended for clarification.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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