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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-429-6 | CAS number: 120-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The SIDS dossier includes proprietary skin and eye irritation studies. Owing to effects observed in acute dermal and inhalation studies and skin and eye irritation studies the substance is regarded as corrosive. Human exposure reports also show the substance to be corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
A skin irritation study was conducted using an 80% solution of the test substance in water. During observation (from 15 minutes to 20 hours) a persistent strong necrosis, oedema and reddening of the skin were observed. The necrosis was not reversible. This study (not performed to GLP) served to classify the substance in the EU as corrosive R34, but the report was not available to the reviewers in the SIDS dossier. So, there are no details available on the purity of the substance, the number and the strain of animals tested and the method employed or guideline followed. In addition, during the course of an acute dermal toxicity study (see section 7.2.3) where the substance was applied in molten form under semiocclusive patches, marked to severe irritation occurred followed by skin necrosis locally at the site of application. Skin lesions were slightly reversible at low doses but were not reversible at high doses after 2 weeks of observation.
With regard to eye irritation, a Dow study noted severe corneal damage in the eyes of rabbits after a single direct application of 0.1 ml of 2,4 -dichlorophenol. After 30 seconds the eyes were washed/rinsed. The washing/rinsing of the eyes did not prevent the corneal damage. In addition, during the course of an acute inhalation toxicity study where the substance was administered as an aerosol at different concentrations, closed eye lids and tears were observed and corneal opacity was noted. Corneal changes were reversible within 24 hours after cessation of exposure.
The information presented above consitutes an assessment of available data on skin irritation/corrosion and eye irritation with regard to 2,4 -dichlorophenol.
Annex VII of Regulation (EC) No 1907/2006 in section 8.1 (with regard to skin irritation/corrosion) and section 8.2 (with regard to eye irritation) states that in vitro studies do not need to be conducted if available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes.
Substantial human case studies have been reported and are documented on the toxnet website - see section 7.10
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
The available information referenced in sections 7.3.1 and 7.3.2 indicate that the substance should be classified as corrosive (irreversible damage recorded on skin and eyes).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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