Registration Dossier
Registration Dossier
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EC number: 204-635-6 | CAS number: 123-56-8
Endpoint summary
Administrative data
Description of key information
Three acute toxicity studie for succinimide are available.
In two acute oral studies an LD50 has been determined of 14 g/kg bw for rats and 11 g/kg bw for mice.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Acute oral toxicity study in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 14 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity in rats, an LD50 value of 14 g/kg bw was determined.
- Executive summary:
In an acute oral toxicity in rats, an LD50 value of 14 g/kg bw was determined.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Acute oral toxicity study in mice
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Specific details on test material used for the study:
- not specified
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 11 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity in mice, an LD50 value of 11 g/kg bw was determined.
- Executive summary:
In an acute oral toxicity in rats, an LD50 value of 11 g/kg bw was determined.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 11 000 mg/kg bw
- Quality of whole database:
- handbook data
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the available data, succinimide does not warrant classification for acute toxicity. The LD50 value for the oral route was above the limit value for classification (2000 mg/kg bw).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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