Registration Dossier
Registration Dossier
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EC number: 233-237-5 | CAS number: 10099-58-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The skin sensitisation of Lanthanum trichloride hexahydrate was investigated in a GLP-study according to OECD 429 (LLNA). CBA mice were treated by topical application with 5, 10 and 25% (w/v) test item for three consecutive days. The exposure to the highest test concentration resulted in a greater than 3-fold increase in incorporation of [³H]TdR compared to the concurrent control (indicated by the stimulation index).
Up to now, no case of contact dermatitis caused by Lanthanum trichloride is reported (Schnuch, A., 2010).
References:
Schnuch, A. (2010). Stellungnahme zur sensibilisierenden Wirkung von Lanthan-tri-chlorid (CAS 10099-58-8) aus Sicht eines epidemiologischen Überwachungssystems.
Migrated from Short description of key information:
Lanthanum trichloride hexahydrate (and corresponding Lanthanum chloride, anhydrous) was sensitising in the LLNA.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
The respiratory sensitisation is not required.
Justification for classification or non-classification
Skin sensitisation
Based on the available data, Lanthanum chloride, anhydrous needs to be classified:
EU: R43
CLP: Category 1 skin sensitisation
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