Registration Dossier
Registration Dossier
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EC number: 236-526-4 | CAS number: 13419-67-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 18, 2016 to March 30, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- The test laboratory is GLP-certified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.15
- Temp.:
- 20 °C
- pH:
- 3.8
- Remarks on result:
- other: ± <0.01
- Details on results:
- The partition coefficient of the test substance 70 % (60 % TLA) was determined at 20 °C. Due to the fact that the partition coefficient log Pow of the test substance was slightly outside the calibrated range (the retention was lower than the one of the reference substance with a log Pow of 1.4), the log Pow was extrapolated to be log Pow = 1.15 ± < 0.01.
- Conclusions:
- Under the study conditions, the partition coefficient of the test substance 70 % (60 % TLA) was determined at 20 °C. Due to the fact that the partition coefficient log Pow of the test substance was slightly outside the calibrated range (the retention was lower than the one of the reference substance with a log Pow of 1.4), the log Pow was extrapolated to be log Pow = 1.15 ± <0.01.
- Executive summary:
A study was conducted to determine partition coefficient according to OECD Guideline 117 and EU Method A.8 (HPLC method). Under the study conditions, the partition coefficient of the test substance 70 % (60 % TLA) was determined at 20 °C. Due to the fact that the partition coefficient log Pow of the test substance was slightly outside the calibrated range (the retention was lower than the one of the reference substance with a log Pow of 1.4), the log Pow was extrapolated to be log Pow = 1.15 ± <0.01 (Möller, 2017).
Reference
Description of key information
The partition coefficient was determined according to OECD Guideline 117 and EU Method A.8 (Möller, 2017).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.15
- at the temperature of:
- 20 °C
Additional information
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