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Diss Factsheets
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EC number: 251-459-0 | CAS number: 33329-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
The substance is is severely irritating and corrosive to the skin, eyes and respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, non guideline study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data.
- GLP compliance:
- not specified
- Species:
- rabbit
- Type of coverage:
- open
- Preparation of test site:
- other: abraded and unabraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5ml
- Duration of treatment / exposure:
- 4-72 hours
- Observation period:
- 30 days
- Number of animals:
- 18
6 per group - Irritation parameter:
- erythema score
- Basis:
- animal: 4 of 5
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: exatrapolated from 48 h erythema score
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: extrapolated from 48 h edema score
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- other: Corrosion score
- Basis:
- mean
- Time point:
- other: 4 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
- Irritation parameter:
- other: Corrosion score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
- Irritation parameter:
- other: Corrosion score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
- Irritation parameter:
- other: Corrosion score
- Basis:
- other:
- Time point:
- other: 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
- Irritation parameter:
- erythema score
- Basis:
- other: 4 of 5
- Time point:
- other: 4 Hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
- Irritation parameter:
- erythema score
- Basis:
- other: 4 of 5
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
- Irritation parameter:
- erythema score
- Basis:
- animal: 4 of 5
- Time point:
- other: 48 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
- Irritation parameter:
- erythema score
- Basis:
- animal: 4 of 5
- Time point:
- other: 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Corrosive effects on intact and abraded skin, not reversible after 30 days.
- Irritant / corrosive response data:
- The substance is severely corrosive to the skin of rabbits. Corrosive effects observed on intact and abraded skin, not reversible after 30 days.
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is severely corrosive to the skin of rabbits. Corrosive effects observed on intact and abraded skin, not reversible after 30 days.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guidleine, non-GLP study.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data.
- GLP compliance:
- no
- Species:
- rabbit
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml of undiluted test substance administered to the eye of each animal.
- Duration of treatment / exposure:
- 5 minute exposure and 24-hour exposure
- Observation period (in vivo):
- Observations at 5 mins, 24hours and 48 hours.
30 days recovery. - Number of animals or in vitro replicates:
- 2 groups of 8
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 5 minutes
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 5-minute exposure
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 5 minute and and 24 hour exposures
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 5 minute and and 24 hour exposures
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 24 hour exposure
- Irritant / corrosive response data:
- The substance is severely corrosive to the eyes of rabbits. Effects were immediate and severe, and irrevesible after a 30-day recovery period.
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is severely corrosive to the eyes of rabbits. Effects were immediate and severe, and irrevesible after a 30-day recovery period.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Irritation study study using the test substance. The substance is is severely irritating and corrosive to the skin, eyes and respiratory tract.
Justification for selection of eye irritation endpoint:
Occular Irritation study study using the test substance. The substance is is severely irritating and corrosive to the skin, eyes and respiratory tract.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Harmful. The substance is is severely irritating and corrosive to the skin, eyes and respiratory tract.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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