Registration Dossier
Registration Dossier
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EC number: 946-056-8 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (14 d) ≥ 15.5 mg/L (28% degradation, OECD 301B)
Key value for chemical safety assessment
Additional information
There is no respiration inhibition study available assessing the toxicity of Hexanedioic acid, di-C16-18 alkyl esters (CAS 92969-90-9) to activated sludge microorganisms. However, a standard ready biodegradability test conducted according to OECD guideline 301 B and GLP is available, whose toxicity control can be used to derive a NOEC. According to the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA, 2017), a concentration can be used as NOEC value, if a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration.
The available study was performed including a toxicity control, which contains 15.5 mg/L of the test item and 40 mg/L of the reference material sodium acetate. The toxicity control attained 28% degradation after 14 days of incubation. Hence, the substance is not toxic to activated sludge microorganisms in the toxicity control and the test item concentration of 15.5 mg/L can be used as NOEC.
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