Registration Dossier
Registration Dossier
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EC number: 947-855-4 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
Data source
Materials and methods
- Principles of method if other than guideline:
- In accordance with REACH Guidance R.7c (Appendix R.7.10-3), fish BCFs of ionised substances can be estimated using appropriate QSARs (e.g. Meylan et al., 1999). The program BCFBAF from EpiSuite version 3.2 uses the QSAR of Meylan et al. (1999).
- GLP compliance:
- no
Test material
- Reference substance name:
- Citric acid
- EC Number:
- 201-069-1
- EC Name:
- Citric acid
- Cas Number:
- 77-92-9
- Molecular formula:
- C6H8O7
- IUPAC Name:
- citric acid
Constituent 1
- Specific details on test material used for the study:
- SMILES : O=C(O)C(O)(CC(=O)O)CC(=O)O
Test conditions
- Details on estimation of bioconcentration:
- BASIS INFORMATION
- Measured/calculated logPow: < 1
BASIS FOR CALCULATION OF BCF
- Estimation software: BCFBAF (part of EpiSuite, version 3.2)
- Result based on measured log Pow of:
- Result based on calculated log Pow of:
Ionic compounds are predicted as follows:
log BCF = 0.50 (log Kow < 5.0)
log BCF = 1.00 (log Kow 5.0 to 6.0)
log BCF = 1.75 (log Kow 6.0 to 8.0)
log BCF = 1.00 (log Kow 8.0 to 9.0)
log BCF = 0.50 (log Kow > 9.0)
Results and discussion
Bioaccumulation factor
- Key result
- Type:
- BCF
- Value:
- 3.16 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- other: estimated
- Remarks on result:
- other: BCFBAF estimated value
- Details on results:
- log BCF = 0.5 for ionic substances with logKow < 5.0
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The logBCF for the test substance as estimated by BCFBAF from EpiSuite version 3.2 using the QSAR of Meylan et al. (1999) was 0.5 (BCF = 3.16 L/kg).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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