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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Remarks:
- in n-octanol
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 Apr - 14 May 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.6
- GLP compliance:
- no
- Medium:
- n-octanol
- Solubility:
- 287.4 mg/L
- Temp.:
- 20 °C
- Test substance stable:
- yes
Reference
Preliminary Test
The preliminary test at room temperature showed, that the octanol solubility of the test item was below 1.6 g/L. The observations of the preliminary test are summarized in Table 1.
Table1: Preliminary test for the octanol solubility
Amount of test item [g] |
Total volume of added octanol [mL] |
Stirring time [min] |
Remark |
0.20 |
5 |
over night |
not dissolved |
25 |
40 |
not dissolved |
|
75 |
190 |
not dissolved |
|
125 |
over night |
not dissolved |
The solubility of the test item in octanol at room temperature was estimated to be < 1.6 g/L. With the estimated water solubility between 169.5 and 1,016.7 g/L of the preliminary test of study CSL-19-0535.04 and the solubility in octanol below 1.6 g/L, determined from this preliminary test, the partition coefficient is estimated to below -2. Due to this result, the flask method for the separate determination of the octanol solubility was performed.
Main Test (flask method)
For the main test three flasks were prepared with an amount of test item and octanol, and one flask only with octanol. After stirring and centrifugation the organic phases were measured by means of HPLC. The solution of each flask has been measured twice. The results of these measurements are shown in Table 2. The values represented in the table are rounded values. The calculation was carried out with the original not rounded values.
Table 2: Results of the flask method
Flask |
1a |
2a |
3a |
4a |
measured value [mg/L] |
253.8 / 253.8 |
297.2 / 298.3 |
283.8 / 283.6 |
0 / 0 |
octanol solubility [mg/L] |
253.8 / 253.8 |
297.2 / 298.3 |
283.8 / 283.6 |
0 / 0 |
average octanol solubility [mg/L] |
253.8 |
297.8 |
283.7 |
0 |
mean value of the octanol solubility [mg/L] |
278.4 |
0 |
||
standard deviation [mg/L] |
22.5 |
-- |
||
relative standard deviation [%] |
8.1 |
-- |
To verify the accuracy of the analytical method fresh prepared standard solutions (prepared with the test item) were measured in between the samples of the flask method. The results of these measurements are shown inTable 3.
Table 3: Measurement of a standard solution
Standard solution (nominal value [mg/L]) |
Measured value [mg/L] |
Repeatability [%] |
Ü-1 (200.8) |
201.51 |
100.4 |
201.77 |
100.5 |
|
203.44 |
101.3 |
|
199.16 |
99.2 |
|
Ü-2 (262.2) |
263.61 |
100.5 |
266.28 |
101.6 |
|
261.30 |
99.7 |
|
263.78 |
100.6 |
The recovery rate of the measured standard solutions was in the range from 99.2 % to 101.6 %, which shows a good accuracy of the analytical method.
Description of key information
Solubility in n-octanol: 278.4 mg/L at 20 °C (OECD 105)
Key value for chemical safety assessment
- At the temperature of:
- 20 °C
- Solubility in organic solvents at 20°C:
- 278.4 mg/L
Additional information
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