Registration Dossier
Registration Dossier
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EC number: 201-920-7 | CAS number: 89-58-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- MUTAGENICITY OF ALIPHATIC AND AROMATIC NITRO COMPOUNDS
- Author:
- KAWAI,A, GOTO,S, MATSUMOTO,Y AND MATSUSHITA,H
- Year:
- 1 987
- Bibliographic source:
- SANGYO IGAKU 29(1):34-55, 1987
- Reference Type:
- secondary source
- Title:
- Chemical Carcinogenesis Research Information System (CCRIS)
- Author:
- Database
- Year:
- 2 012
- Bibliographic source:
- Database of the National Library of Medicine's TOXNET system (http://toxnet.nlm.nih.gov) on August 27, 2012.
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-nitro-p-xylene
- EC Number:
- 201-920-7
- EC Name:
- 2-nitro-p-xylene
- Cas Number:
- 89-58-7
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 1,4-dimethyl-2-nitrobenzene
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 98
- Species / strain / cell type:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat liver
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
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