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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

Long-term toxicity to aquatic invertebrates:
Conclusion: Results of two studies show that DTDP will not produce chronic toxicity to invertebrates at or below its maximum attainable water solubility.

Key value for chemical safety assessment

Additional information

Both substances named DTDP are high molecular weight phthalate esters (C13), diisotridecyl phthalate (CAS number 27253-26-5, EC number 248-368-3) and 1,2-Benzenedicarboxylic acid, di-C11-14-branched alkyl esters, C13-rich (CAS number 68515-47-9, EC number 271-089-3). Both are isomeric mixtures of C13 branched alkyl esters, the starting material being different but both starting materials consisting of various isomers of multibranched C13 alcohols.

The results of long-term toxicity studies are reported as EC50and NOEC values for chronic invertebrate toxicity. The NOEC values represent the highest concentration measured in these studies that did not demonstrate effects. In all cases this was the highest concentration attainable and measured under the conditions of the study. The use of the NOEC values in the results overview table to derive values for quantitative risk assessment is inappropriate as they are not true NOEC values.

Results from long-term toxicity studies with an invertebrate show that DTDP does not cause chronic toxicity at the maximum achievable aqueous concentrations investigated in these tests (i.e. in excess of water solubility). The studies tested DTDP up to its solubility limit under the conditions of the studies. In comparison, the Brownet al.(1998) study used a surfactant to achieve an exposure solution with a stable emulsion of DTDP at a level that far exceeded its water solubility. The use of a surfactant in comparison to the study that did not use a surfactant explains the large difference in the reported EC50and NOEC values.

I5 Summary

The data used to characterize the invertebrate chronic toxicity of di-isotridecyl phthalate (DTDP) ester are consistent with the data for several high molecular weight phthalate diesters summarized by Staples et al. (1997). These data show that high molecular weight phthalate diesters do not produce chronic toxicity to invertebrates at or below their maximum attainable solubliity. The acute invertebrate dataset includes results for one species, Daphnia magna.

Staples et al. (1997). Aquatic toxicity of eighteen phthalate esters. Environ. Toxicol. Chem. 16(5): 875 -891.