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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
08 June 2016 - 17 June 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Specific details on test material used for the study:
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: before tesing the substance was under vacuum for approximately 54.5 hours.
Key result
Temp.:
25 °C
Vapour pressure:
13 Pa

The values of vapor pressure at 25 °C extrapolated from each graph (Graph of Log10 Vapor Pressure vs Reciprocal Temperature) are summarized in the following table:

Table 11. Summary of Vapor Pressure Data

Run Logio[Vp(25°C)]
1 0.580
2 0.982
3 0.926
4 1.05
5 1.30
6 1.17
7 1.22
8 1.16
9 1.38
10 1.41
Mean 1.12
Vapor Pressure 13.2 Pa

The test item did not change in appearance under the conditions used in the determination.

Conclusions:
The vapor pressure of the test item has been determined to be 13 Pa at 25 ºC.
Executive summary:

The vapor pressure of N-butylpyrrolidone has been determined to be 13 Pa at 25 °C, using the vapor pressure balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Description of key information

The vapour pressure of N-Butylpyrrolidone was determined as 13 Pa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:
13 Pa
at the temperature of:
25 °C

Additional information

The vapor pressure of N-butylpyrrolidone has been determined to be 13 Pa at 25 °C, using the vapor pressure balance method, designed to be compatible with Method A.4 (Regulation (EC) No 440/2008) and OECD test guideline104.

In a disregarded study, the vapour pressure of N-Butylpyrrolidone was determined by the Static method - using a U-tube manometer. The test was conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A, test A.4. The vapour pressure of N-Butylpyrrolidone was detected as 35 Pa (0.35 mbar) at 20 °C. The study is however desregarded because the sample tested was a pre-production sample not representing the final product, and the method used was a less accurate method for low volatility substances.