Dodecan-5-olide

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

for read across substance

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two short term toxicity study of fish for the test chemical :
2.To study the effects of test material, toxicity to aquatic algae and cyanobacteria test was carried out for 72 hr.
3.To evaluate toxicity of test material on Chlorococcales

GLP compliance:

not specified

Analytical monitoring:

not specified

Test organisms (species):

other: 2.Desmodesmus subspicatus , 3.Chlorococcum sp.

Details on test organisms:

2.common name: Green Algae
age: Exponential growth phase (log)
COMMENT: 10000 CELLS/ML

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

Test temperature:

23 deg C

Details on test conditions:

3 REPLICATES, MINERAL SALT TEST MEDIUM

Reference substance (positive control):

not specified

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

6.61 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: 95% conf. limit : 5.78 - 7.63 mg/L

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

230 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

biomass

Validity criteria fulfilled:

not specified

Conclusions:

The test chemical is likely to be not toxic to aquatic algae and cyanobacteria in the dose range of 230 mg/l.The BCF value of test chemical reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of aquatic algae and cyanobacteria of the test chemical .The studies are as mentioned below:

To study the effects of test material toxicity to aquatic algae and cyanobacteria test was carried out for 72 hr.

Effective concentration EC50 to 50% of Desmodesmus subspicatus when expeosed to test material for 72 hr is 6.61 mg/L.

The BCF value of test material reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

In another data for similar read across substance test material was used to evaluate its toxicity on Chlorococcales green algae for 24 hrs in static condition . The effect concentration (EC50) at which population of algae was effect was observed to be 230 mg/l.

The test chemical is not likely to be toxic to aquatic algae and cyanobacteria  in the dose range of 230 mg/l.The BCF value of test chemical reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

Description of key information

Toxicity to aquatic algae and cyanobacteria:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of aquatic algae and cyanobacteria of the test chemical .The studies are as mentioned below:

To study the effects of test material toxicity to aquatic algae and cyanobacteria test was carried out for 72 hr.Effective concentration EC50 to 50% of Desmodesmus subspicatus when expeosed to test material for 72 hr is 6.61 mg/L.The BCF value of test material reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

In another data for similar read across substance test material was used to evaluate its toxicity on Chlorococcales green algae for 24 hrs in static condition . The effect concentration (EC50) at which population of algae was effect was observed to be 230 mg/l.

The test chemical is not likely to be toxic to aquatic algae and cyanobacteria  in the dose range of 230 mg/l.The BCF value of test chemical reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

Key value for chemical safety assessment

EC50 for freshwater algae:

6.61 mg/L

Additional information

Toxicity to aquatic algae and cyanobacteria:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of aquatic algae and cyanobacteria of the test chemical .The studies are as mentioned below:

To study the effects of test material toxicity to aquatic algae and cyanobacteria test was carried out for 72 hr.Effective concentration EC50 to 50% of Desmodesmus subspicatus when expeosed to test material for 72 hr is 6.61 mg/L.The BCF value of test material reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.

In another data for similar read across substance test material was used to evaluate its toxicity on Chlorococcales green algae for 24 hrs in static condition . The effect concentration (EC50) at which population of algae was effect was observed to be 230 mg/l.

The test chemical is not likely to be toxic to aquatic algae and cyanobacteria  in the dose range of 230 mg/l.The BCF value of test chemical reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.