Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In the key oral toxicity study (Huls AG, 1993), the LD50 was determined to be 200 mg/kg and >200 mg/kg for male and female rats respectively. 4/4 animals died when dose at 2000 mg/kg. Necrospy findings were consistent with corrosive effects of the test substance. There are no data for the inhalation and dermal routes of exposure. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
200 mg/kg bw

Additional information

The key study is the only available study for acute toxicity. The study was comparable to the now-deleted OECD 401, with some deviations, and was compliant with GLP. No data are available for the inhalation and dermal routes.

Justification for classification or non-classification

On the basis of the available acute oral toxicity study, trichloroisobutylsilane is classifed R22 "Harmful if swallowed" according to the criteria of EU Directive 67/548/EEC and Acute toxic 3 (oral) under Regulation 1272/2008.

There are no data to support classification for acute dermal or inhalation toxicity.