Registration Dossier
Registration Dossier
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EC number: 231-658-9 | CAS number: 7680-73-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No test guideline followed, inadequate documentation, limited information on purity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of nicotinic acid and some of its derivatives
- Author:
- Brazda FG & Coulson RA
- Year:
- 1 946
- Bibliographic source:
- P. Soc. exp. Biol. Med. (1946), 62, 19-20
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpyridinium chloride
- EC Number:
- 231-658-9
- EC Name:
- 1-methylpyridinium chloride
- Cas Number:
- 7680-73-1
- Molecular formula:
- C6H8ClN
- IUPAC Name:
- 1-methylpyridin-1-ium chloride
- Details on test material:
- Analytical purity: highly purified test material
Name of test material (as cited in publication):pyridine methochloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- young rats of both sexes weighing between 50 and 100 g
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Details on exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 280 mg/kg bw
- Based on:
- not specified
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
