Registration Dossier
Registration Dossier
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EC number: 231-658-9 | CAS number: 7680-73-1
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- combined repeated dose and reproduction / developmental screening
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No test guideline followed, inadequate documentation, no indication of purity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Long-term effects of N-methylpyridinium chloride on the target organism
- Author:
- Antonenko T, Nechkina M, Nakoryakova M, Kulikova L & Chomutova T
- Year:
- 1 984
- Bibliographic source:
- Gigiena i Sanitariya (1984), 49(1), 74-75 (publication written in Russian)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The Methodological Guidelines for Hygienic Assessment of New Pesticides (Kiev, 1969).
The Analytical Research Methods of Assessment of Threshold Effects of Industrial Poisons on the Generative Function with the Purpose of Developing Hygienic Regulations (Moscow, 1978). - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpyridinium chloride
- EC Number:
- 231-658-9
- EC Name:
- 1-methylpyridinium chloride
- Cas Number:
- 7680-73-1
- Molecular formula:
- C6H8ClN
- IUPAC Name:
- 1-methylpyridin-1-ium chloride
- Details on test material:
- analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: white rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Administration of test substance into stomach.
- Analytical verification of doses or concentrations:
- not specified
- No. of animals per sex per dose:
- embryotropic effects: 39 white rats & 250 embryos
gonadotropic effects: 48 male white rats - Control animals:
- yes, concurrent no treatment
Results and discussion
Results of examinations
- Details on results:
- The substance had mild cumulative property and its chronic threshold dose was 4.53 mg/kg. It showed no embryotropic effect at 1/500 and 1/5000 LD50. It also had no effects on the gonads when given to rats at 1/50, 1/500, 1/5000 LD50 for 6 months.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
