Registration Dossier
Registration Dossier
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EC number: 202-257-6 | CAS number: 93-55-0
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials: Acetophenone.
- Author:
- Opdyke D.L.J
- Year:
- 1 973
- Bibliographic source:
- Food and Cosmetics Toxicology, 11: 99-100
- Reference Type:
- other: reference mentioned into the monograph
- Title:
- -
- Author:
- Kligman, A. M.
- Year:
- 1 971
- Bibliographic source:
- Report to RIFM, 9 June.
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Substance tested at a concentration of 2 % in petrolatum, in a 48-hr closed-patch test (25 subjects).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-phenylethanone
- IUPAC Name:
- 1-phenylethanone
Constituent 1
Method
- Details on study design:
- - Concentration: 2 % in petrolatum- Exposure period: 48-hr - Test system: closed-patch test - N. of subjects: 25 human
Results and discussion
- Results:
- Substance tested at a concentration of 2 % in petrolatum produced no irritation in a 48-hr closed-patch test in 25 human subjects..
Applicant's summary and conclusion
- Conclusions:
- The substance tested at a concentration of 2 % in petrolatum produced no irritation in a 48-hr closed-patch test in 25 human subjects.
- Executive summary:
The substance tested at a concentration of 2 % in petrolatum produced no irritation in a 48-hr closed-patch test in 25 human subjects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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