Registration Dossier
Registration Dossier
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EC number: 261-819-9 | CAS number: 59587-44-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on freshwater fish up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the short-term toxicity of 2-ethylhexanol nonanoate (CAS
59587-44-9) to fish are not available. The assessment was therefore
based on a study conducted with the structurally similar substance Fatty
acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2), as part of a read
across approach, which is in accordance with Regulation (EC) No.
1907/2006, Annex XI, 1.5. Further justification is given within the
endpoint summary 6.1 and within the analogue justification.
The short-term toxicity of Fatty acids, C8-16, 2-ethylhexyl esters (CAS
135800-37-2) was tested under semi-static conditions according to EU
Method C.1 (Wierich 1998). Zebra fish (Danio rerio) were exposed to the
substance at concentrations of 1000, 3000 and 10000 mg/L. There were no
toxic or sublethal effects at any concentration after an incubation
period of 96 hours observed, resulting in an EC50 (96h) >10000 mg/L
(nominal). Thus, toxic effects were not observed within the range of the
water solubility.
Thus, based on the above mentioned result, and due to the structural and
profile similarities of the substances, as are explained with in the
overall endpoint summary 6.1 it can be concluded that no toxicological
effects on fish are expected up tothe limit ofwater solubility for
2-ethylhexanol nonanoate (CAS 59587-44-9).
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