Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Case Report
Adequacy of study:
supporting study
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No significant deficiencies in study design and evaluation.

Data source

Reference Type:
Allergic contact dermatitis from selenite
Senff H et al
Bibliographic source:
Contact dermatitis, 1988, 19/1, 73 -74

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin sensitisation
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium selenite
EC Number:
EC Name:
Sodium selenite
Cas Number:
Molecular formula:
disodium selenite
Details on test material:
- Name of test material (as cited in study report): Sodium selenite


Type of population:
One female technician
15 control subjects not further specified
Ethical approval:
not specified
Route of exposure:

Results and discussion

Results of examinations:
Positive patch test in one technician
Negative in 15 control persons

Any other information on results incl. tables

A laboratory technician had worked in the culture medium kitchen of a veterinary research institute.

After 6 months small severely-pruritic vesicles were occurred between the fingers, which were excoriated and healed without scarring. Similar symptoms then reappeared every 6 to 8 weeks (later on, even if gloves were worn) whenever she worked with the selenite-cystine enrichment broth.

Hand eczema improved or healed at weekends and during time away from work.

Symptoms increased after she had worked for 2 years in the culture-medium kitchen. Apart from eczema on the hands, eczema now also affected the face and neck, with watering eyes. Additionally two asthma attacks occurred within 2 month.

Patch testing with a standard series, disinfectants, preservatives and drugs was negative. The selenite-cystine enrichment broth and its individual ingredients were tested.

Sodium selenite showed a threefold positive reaction down to an aqueous dilution of 1:1000. There were no other positive reactions. Intracutaneous testing with common inhalants and the individual ingredients of the selenite –cystine enrichment broth was negative.

RASTs for common inhalants using peptone and selenite were negative.

The same tests in 15 control subjects were also negative.

Applicant's summary and conclusion

Positive patch test in one female technician, however RASTs for common inhalants using peptone and selenite were negative.
The same tests in 15 control subjects were also negative.