Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 12 June 2008 and 08 July 2008.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
With the exception of the explosive and oxidising properties predictions the work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
Type of method:
effusion method: vapour pressure balance

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Vapour pressure
Temp.:
25 °C
Vapour pressure:
< 0 Pa

Any other information on results incl. tables

Results

Run 1

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10 Vp

240

513.15

0.001948748

1.95

1.950E-09

0.002707100

-2.567495767

241

514.15

0.001944958

0.57

5.700E-10

0.000791306

-3.101655523

242

515.15

0.001941182

1.22

1.220E-09

0.001693673

-2.771170548

243

516.15

0.001937421

0.98

9.800E-10

0.001360491

-2.866304303

244

517.15

0.001933675

1.30

1.300E-09

0.001804733

-2.743587026

245

518.15

0.001929943

1.06

1.060E-09

0.001471552

-2.832224513

246

519.15

0.001926226

1.38

1.380E-09

0.001915794

-2.717651292

247

520.15

0.001922522

0.16

1.600E-10

0.000222121

-3.653410396

248

521.15

0.001918833

0.33

3.300E-10

0.000458125

-3.339016439

249

522.15

0.001915158

1.22

1.220E-09

0.001693673

-2.771170548

250

523.15

0.001911498

-0.24

-2.400E-10

-

-

No statistical analysis is given due to the nature of the plot

Run 2

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10 Vp

240

513.15

0.001948748

-0.24

-2.400E-10

-

-

241

514.15

0.001944958

0.73

7.300E-10

0.001013427

-2.994207519

242

515.15

0.001941182

0.24

2.400E-10

0.000333181

-3.477319137

243

516.15

0.001937421

1.55

1.550E-09

0.002151797

-2.667198681

244

517.15

0.001933675

-0.08

-8.000E-11

-

-

245

518.15

0.001929943

0.73

7.300E-10

0.001013427

-2.994207519

246

519.15

0.001926226

-1.63

-1.630E-09

-

-

247

520.15

0.001922522

0.33

3.300E-10

0.000458125

-3.339016439

248

521.15

0.001918833

0.41

4.100E-10

0.000569185

-3.244746522

249

522.15

0.001915158

-0.08

-8.000E-11

-

-

250

523.15

0.001911498

0.33

3.300E-10

0.000458125

-3.339016439

No statistical analysis is given due to the nature of the plot

Run 3

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10 Vp

240

513.15

0.001948748

0.65

6.500E-10

0.000902367

-3.044617022

241

514.15

0.001944958

0.08

8.000E-11

0.000111060

-3.954440392

242

515.15

0.001941182

0.90

9.000E-10

0.001249431

-2.903287869

243

516.15

0.001937421

0.90

9.000E-10

0.001249431

-2.903287869

244

517.15

0.001933675

-0.24

-2.400E-10

-

-

245

518.15

0.001929943

1.87

1.870E-09

0.002596039

-2.585688772

246

519.15

0.001926226

0.16

1.600E-10

0.000222121

-3.653410396

247

520.15

0.001922522

-0.16

-1.600E-10

-

-

248

521.15

0.001918833

-0.24

-2.400E-10

-

-

249

522.15

0.001915158

1.14

1.140E-09

0.001582612

-2.800625527

250

523.15

0.001911498

0.00

0.000E+00

-

-

No statistical analysis is given due to the nature of the plot

Run 4

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10 Vp

240

513.15

0.001948748

0.57

5.700E-10

0.000791306

-3.101655523

241

514.15

0.001944958

0.24

2.400E-10

0.000333181

-3.477319137

242

515.15

0.001941182

0.98

9.800E-10

0.001360491

-2.866304303

243

516.15

0.001937421

1.14

1.140E-09

0.001582612

-2.800625527

244

517.15

0.001933675

0.98

9.800E-10

0.001360491

-2.866304303

245

518.15

0.001929943

0.16

1.600E-10

0.000222121

-3.653410396

246

519.15

0.001926226

0.41

4.100E-10

0.000569185

-3.244746522

247

520.15

0.001922522

1.06

1.060E-09

0.001471552

-2.832224513

248

521.15

0.001918833

1.30

1.300E-09

0.001804733

-2.743587026

249

522.15

0.001915158

0.16

1.600E-10

0.000222121

-3.653410396

250

523.15

0.001911498

0.73

7.300E-10

0.001013427

-2.994207519

No statistical analysis is given due to the nature of the plot

Run 5

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10 Vp

240

513.15

0.001948748

0.24

2.400E-10

0.000333181

-3.477319137

241

514.15

0.001944958

0.41

4.100E-10

0.000569185

-3.244746522

242

515.15

0.001941182

0.00

0.000E+00

-

-

243

516.15

0.001937421

1.71

1.710E-09

0.002373918

-2.624534268

244

517.15

0.001933675

0.73

7.300E-10

0.001013427

-2.994207519

245

518.15

0.001929943

0.41

4.100E-10

0.000569185

-3.244746522

246

519.15

0.001926226

-0.08

-8.000E-11

-

-

247

520.15

0.001922522

0.65

6.500E-10

0.000902367

-3.044617022

248

521.15

0.001918833

0.90

9.000E-10

0.001249431

-2.903287869

249

522.15

0.001915158

0.00

0.000E+00

-

-

250

523.15

0.001911498

-0.33

-3.300E-10

-

-

No statistical analysis is given due to the nature of the plot

Discussion

No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning.  Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25ºC.

Run 5 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete.  The reading at 243ºC (516.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1500 K is imposed upon it.

The value of –1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method.  Extrapolation to 25ºC gave a vapour pressure of 1.781 x 10-5 Pa which has been taken as a maximum for this material.

The test material did not change in appearance under the conditions used in the determination

Conclusion

The vapour pressure of the test material has been determined to be less than 1.8 x 10-5 Pa at 25ºC.

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test material has been determined to be less than 1.8 x 10-5 Pa at 25ºC.
Executive summary:

For substance Na-Na in project number 1307 -0437 the vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C.  Testing was conducted using Method A4 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC). The vapour pressure of the test material has been determined to be less than 1.8 x 10-5 Pa at 25ºC.