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EC number: 202-216-2 | CAS number: 93-08-3
Endpoint summary
Administrative data
Description of key information
Short-Term Toxicity to Fish
The study outlines the effect of test chemical on the aquatic test modeldanio rerio. This test was performed by following the OECD guidelines 203- Fish Acute Toxicity Test. Five different test concentrations was taken ranging from 0.3125 to 5 mg/L by following the geometric series of factor 2. The test was performed for 96 hrs, and mortality was recorded for every interval of 24 hours up to 96 hours.
Based on the mortality observed in exposed tenure, the observed median lethal concentration of the test chemical is (LC50) 5.0mg/L. The test chemical is toxic to the aquatic environment and it can be classified as aquatic chronic category 2.
Long-Term Toxicity to Fish
The 28 days chronic toxicity to fish was predicted by using the ECOSAR 1.11 version. The predicted NOEC value for test chemical was 2.587 mg/L. This NOEC suggests that test chemical could not exhibit long term toxicity to fish and thus can be considered to not classified according to CLP criteria.
Short-Term Toxicty to Aquatic Invertebrates
The Daphnia magna immobilizationtest was performed for the test chemical by following the OECD guideline 202. the test chemical was poorly soluble in water, and acetone has been used as the carrier solvent. the test was performed for the period of 48 hours. The test was conducted by taking the five different test concentrations i.e., 1.2, 2.5, 5, 10, 20, 30, and 40 mg/L, along with solvent control (K2Cr2O7).
On the basis of mobility of daphnia, the test chemical EC50 was determined 48.1 mg/L with confidence intervals of 39.3 and 58.9. Based on the median effective concentration of test chemical it can be classified into aqucatic chronic 3 category.
Long-Term Toxicty to Aquatic Invertebrates
The 21 days chronic toxicity to fish (ChV) was predicted using the ECOSAR 1.11 version. The predicted ChV value for test chemical was 1.798 mg/L. Based on the ChV chemical cannot be classified as per CLP category
Toxicity to Aquatic Algae and Cyanobacteria
The study is to evaluate the effect of chemical test chemical when comes in contact with the test organism Desmodesmus subspicatus (previous name: Scenedesmus subspicatus). Test was conducted according to the OECD guideline 201. Various concentrations ranging from 2.0 to 21.0 mg/L, along with one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. Effect on the growth of algae was determine after an exposure period of 72 hrs.
The median effective concentration (EC50) for the test substance, in algae was determined to be 8.9 mg/L on the basis of growth rate inhibition effects in a 72 hour study. Based on the EC50 value, the test chemical can be classified into aquatic chronic category 2 as per CLP classification.
Toxicity to Microorganisms
In different studies, the given test chemical, has been investigated for toxicity to microorganisms to a greater or lesser extent. The studies are summarized as below –
In this study both the test chemicals were studied to understand its effects on microorganisms, both the tests were performed in the static regime and the inhibitory growth concentration (IGC50) value was determined. In the first WoE experiment tenure was for 60 hours and the second WoE study was for 48 hours.
It was determined that the IGC for study 2 and study 3 is 60.61 and 17 mg/L respectively
Thus from the above effects chemical toxicity value ranges from 17 -60.61 mg/L
Additional information
Short-Term Toxicity to Fish
The study outlines the effect of test chemical on the aquatic test modeldanio rerio. This test was performed by following the OECD guidelines 203- Fish Acute Toxicity Test. Five different test concentrations was taken ranging from 0.3125 to 5 mg/L by following the geometric series of factor 2. The test was performed for 96 hrs, and mortality was recorded for every interval of 24 hours up to 96 hours.
Based on the mortality observed in exposed tenure, the observed median lethal concentration of the test chemical is (LC50) 5.0mg/L.
Thus, the test chemical is toxic to the aquatic environment and it can be classified as aquatic chronic category 2.
Long-Term Toxicity to Fish
The 28 days chronic toxicity to fish was predicted by using the ECOSAR 1.11 version. The predicted NOEC value for test chemical was 2.587 mg/L. This NOEC suggests that test chemical could not exhibit long term toxicity to fish and thus can be considered to not classified according to CLP criteria.
Short-Term Toxicty to Aquatic Invertebrates
TheDaphnia magnaimmobilizationtest was performed for the test chemical by following the OECD guideline 202. the test chemical was poorly soluble in water, and acetone has been used as the carrier solvent. the test was performed for the period of 48 hours. The test was conducted by taking the five different test concentrations i.e., 1.2, 2.5, 5, 10, 20, 30, and 40 mg/L, along with solvent control (K2Cr2O7).
On the basis of mobility of daphnia, the test chemical EC50 was determined 48.1 mg/L with confidence intervals of 39.3 and 58.9.
Thus, based on the median effective concentration of test chemical it can be classified into aqucatic chronic 3 category.
Long-Term Toxicty to Aquatic Invertebrates
The 21 days chronic toxicity to fish (ChV) was predicted using the ECOSAR 1.11 version. The predicted ChV value for test chemical was 1.798 mg/L. Based on the ChV chemical cannot be classified as per CLP category
Toxicity to Aquatic Algae and Cyanobacteria
The study is to evaluate the effect of chemical test chemical when comes in contact with the test organism Desmodesmus subspicatus (previous name: Scenedesmus subspicatus). Test was conducted according to the OECD guideline 201. Various concentrations ranging from 2.0 to 21.0 mg/L, along with one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. Effect on the growth of algae was determine after an exposure period of 72 hrs.
The median effective concentration (EC50) for the test substance, in algae was determined to be 8.9 mg/L on the basis of growth rate inhibition effects in a 72 hour study.
Thus, based on the EC50 value, the test chemical can be classified into aquatic chronic category 2 as per CLP classification.
Toxicity to Microorganisms
In different studies, the given test chemical, has been investigated for toxicity to microorganisms to a greater or lesser extent. The studies are summarized as below –
In this study both the test chemicals were studied to understand its effects on microorganisms, both the tests were performed in the static regime and the inhibitory growth concentration (IGC50) value was determined. In the first WoE experiment tenure was for 60 hours and the second WoE study was for 48 hours.
It was determined that the IGC for study 2 and study 3 is 60.61 and 17 mg/L respectively
Thus from the above effects chemical toxicity value ranges from 17 -60.61 mg/L
Based on the outcomes from the aquatic toxicity the test chemical can be classified into aquatic chronic 2 category.
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