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EC number: 695-757-2 | CAS number: 897381-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4/6/2013-10/6/2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted at a GLP accredited laboratory
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Oxirane, 2-ethyl-, homopolymer, ether with 1,2-ethanediol (2:1)
- IUPAC Name:
- Oxirane, 2-ethyl-, homopolymer, ether with 1,2-ethanediol (2:1)
- Reference substance name:
- 1-[2-(2-hydroxybutoxy)ethoxy]butan-2-ol
- EC Number:
- 695-757-2
- Cas Number:
- 897381-19-0
- Molecular formula:
- UVCB
- IUPAC Name:
- 1-[2-(2-hydroxybutoxy)ethoxy]butan-2-ol
- Details on test material:
- Clear light yellow liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The animals were randomly assigned to the study based upon sex, body weight and apparent good health.The rabbits were given the following identification numbers and identified by ear tag numbers 622-624.
Age Range: App. 11 weeks at start of dosing; records of dates of birth for animals used in this study are retained in the Calvert archives.
Body Weight Range: 2.6 to 2. 7 kilograms at the outset (Day 1) of the study.
Animal Source: Millbrook
Experimental History: Purpose-bred and experimentally naive at the outset of the study.
Housing: Animals were individually housed in compliance with USDA Guidelines. The room in which the animals were kept was documented in the study records. No other species were kept in the same room.
Lighting: 12 hours light/12 hours dark
Room Temperature: 17-21 C degrees
Relative Humidity: 43to 78%
Food: All animals had access to PMI Certified Hi-Fiber Rabbit Ojet #5325 as per Calvert SOP. The lot number(s) and specifications of each lot used are archived at Calvert. No contaminants were known to be present in the certified diet at levels that would be expected to interfere with the results of this study. Analysis of the diet was limited to that performed by the manufacturer records of which are maintained in the Calvert archives.
Water: Water was available ad libitum to each animal via an automatic watering device. The water is routinely analyzed for contaminants as per Calvert SOP's. No contaminants were known to be present in the water at levels that would be expected to interfere with the results of this study.
Acclimation: Study animals were acclimated to their housing for a minimum of five days prior to dosing.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- The test article was dosed neat as received directly on intact, delinated skin sites. 0.5 mL of liquid test article was applied to each of the test sites.
- Duration of treatment / exposure:
- The exposure periods were 3 and 60 minutes and 4 hours, respectively. Following observation of this animal, two rabbits were dosed with the test article with an exposure period of 4 hours.
- Observation period:
- Observations for dermal irritation were recorded for the initial rabbit immediately after patch removal, at 30-60 minutes and dai1y through Day 4 for the 3 minute and 60 minute exposures. Observations for dermal irritation were recorded for the 4 hour exposure sites at 30-60 minutes post-dose and at 24, 48 and 72 hours. Grading of irritation was according to the method of Draize.
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 622M
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: 4h exposure
- Irritation parameter:
- edema score
- Basis:
- animal: 622M
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: 4h exposure
- Irritation parameter:
- erythema score
- Basis:
- animal: 623M
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: 4h exposure
- Irritation parameter:
- edema score
- Basis:
- animal: 623M
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: 4H exposure
- Irritation parameter:
- erythema score
- Basis:
- animal: 624M
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: 4h exposure
- Irritation parameter:
- edema score
- Basis:
- animal: 624M
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: 4h exposure
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 60 min
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: very slight erythema of one animal on Day 2, resolving by Day 3
- Irritant / corrosive response data:
- The most severe dermal responses observed were very slight erythema of one animal on Day 2, resolving by Day 3 after 60 mins exposure.
- Other effects:
- No mortality was observed during the study. No clinical signs were recorded during the course of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Precursor PO 206 was found to be non-irritating according to the EEC Irritation Rating and the GHS Classification. The Primary Irritation Index was 0.0.
- Executive summary:
The purpose of this study was to determine the potential irritant and/or corrosive effects of the test article on the skin of rabbits. Precursor PO 206 was administered dermally to three New Zealand White rabbits at 0.5 mL per site. The exposure periods were 3 and 60 minutes and/or 4 hours, respectively.
The most severe dermal responses observed were very slight erythema of one animal on Day 2, resolving by Day 3 after 60 mins exposure. PO 206 was found to be non-irritating according to the EEC Irritation Rating and the GHS Classification. The Primary Irritation Index was 0.0.
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