Registration Dossier
Registration Dossier
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EC number: 612-179-8 | CAS number: 61597-98-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Menthyl lactate is significantly metabolized by hepatocytes of humans: 94 % within 15 min.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No ADME and dermal absorption studies with Menthyl lactate are available.
After dermal application of 10000 mg test substance/kg bw in rat acute toxicity study no systemic effects could be observed. The octanol/water partition coefficient of 3.71 (22.6 °C) indicates lipophilic property of the substance and, also considering the low molecular weight of 228.33 g/mol it can be assumed that the substance penetrates to some extent through the skin. The substance Menthyl lactate is a liquid at room temperature with the vapour pressure of 0.007 Pa (20 °C) and is considered as low volatility substance, therefore inhalation exposure may be neglected. In the study with human hepatocytes (Schneider, 2013) it was shown that L-Menthyl lactate (Frescolat® ML) depletes by about 94 % within 15 minutes.
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